Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues
Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues
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DOI：
10.1086/651457
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发表时间：
2010-04-15
影响因子：
6.4
通讯作者：
Xu, Xiao-Ning
中科院分区：
文献类型：
--
作者：
Shu, Yuelong;Li, Chris Ka-fai;Xu, Xiao-Ning
人类呼吸道是禽流感A（H5N1）感染的主要部位。然而，许多感染H5N1的人出现胃肠道症状，这表明这也可能是病毒的目标。在这项研究中，我们证明，人类肠道表达丰富的禽H5N1受体，很容易感染H5N1病毒离体，并产生感染性病毒颗粒在器官培养。H5N1感染患者的尸检结肠样本显示肠道上皮细胞中存在病毒抗原表达的证据。据我们所知，我们的研究结果提供了H5N1可以直接靶向人类肠道组织的第一个证据。
The human respiratory tract is a major site of avian influenza A(H5N1) infection. However, many humans infected with H5N1 present with gastrointestinal tract symptoms, suggesting that this may also be a target for the virus. In this study, we demonstrated that the human gut expresses abundant avian H5N1 receptors, is readily infected ex vivo by the H5N1 virus, and produces infectious viral particles in organ culture. An autopsy colonic sample from an H5N1-infected patient showed evidence of viral antigen expression in the gut epithelium. Our results provide the first evidence, to our knowledge, that H5N1 can directly target human gut tissues.