Prognostic significance of augmented metallothionein (MT) expression correlated with Ki-67 antigen expression in selected soft tissue sarcomas
Prognostic significance of augmented metallothionein (MT) expression correlated with Ki-67 antigen expression in selected soft tissue sarcomas
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DOI：
10.14670/hh-20.83
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发表时间：
2005-01-01
影响因子：
2
通讯作者：
Zabel, M
中科院分区：
文献类型：
--
作者：
Dziegiel, P;Salwa-Zurawska, W;Zabel, M
在软组织肉瘤中，最重要的预后标准包括恶性程度（G）、肿瘤大小和Ki-67抗原表达强度：最近发现，在上皮来源的某些恶性过程的细胞中金属硫蛋白（MT）的表达与Ki-67抗原表达强度相关，并具有可能的预后意义。本研究旨在证明MT表达的预后价值，并将其与选定软组织肉瘤中Ki-67抗原表达和G级进行比较。对54例恶性纤维组织细胞瘤（MFH）、18例脂肪肉瘤和20例滑膜肉瘤进行了免疫组织化学研究。MT和Ki-67抗原表达的程度进行了评估，并试图将结果相互关联，并与肿瘤的等级。MT在所有研究的肉瘤的细胞质和细胞核中都有明显的表达。最明显的MT表达在MFH型肿瘤中。Ki-67抗原表达的程度在MFH和脂肪肉瘤中相似，在滑膜肉瘤中最低。在MFH、脂肪肉瘤和滑膜肉瘤中，MT和Ki-67抗原表达之间存在明显的正相关性（r=0.85; p
In soft tissue sarcomas, the most important prognostic criteria include extent of malignancy (G), size of the tumour and intensity of Ki-67 antigen expression: In recent times expression of metallothionein (MT) in cells of some malignant processes of epithelial origin was found to correlate with intensity of Ki-67 antigen expression and to carry a possible prognostic significance. The present study aimed at a demonstration of prognostic value of MT expression and at comparing it with Ki-67 antigen expression and G grade in selected soft tissue sarcomas. Immunohistochemical studies were performed on paraffin sections in 54 cases of malignant fibrous histiocytoma (MFH), 18 cases of liposarcoma and 20 cases of synovial sarcoma. The extent of MT and Ki-67 antigen expression was evaluated and an attempt was made to correlate the results with each other and with grade of the tumour. Expression of MT was evident both in the cytoplasm and in cell nuclei of all studied sarcomas. The most pronounced MT expression was noted in MFH-type tumours. The extent of Ki-67 antigen expression was similar in MFH and liposarcoma and was the lowest in synovial sarcoma. In MFH, liposarcoma and synovial sarcoma a pronounced positive correlation was documented between expression of MT and Ki-67 antigen (r=0.85; p