SEBS block copolymers as novel materials to design transdermal patches
SEBS block copolymers as novel materials to design transdermal patches
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DOI：
10.1016/j.ijpharm.2019.118975
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发表时间：
2020-02-15
影响因子：
5.8
通讯作者：
Cilurzo, Francesco
中科院分区：
文献类型：
--
作者：
Gennari, Chiara Grazia Milena;Quaroni, Gaia Maria Giorgia;Cilurzo, Francesco
苯乙烯-嵌段-（乙烯-共-丁烯）-嵌段-苯乙烯（SEBS）共聚物是生物相容性弹性体，对紫外线辐射具有出色的稳定性。这项工作解决了这类弹性体的透皮贴剂的发展潜力。SEBS分子量、增塑剂和增粘剂类型对流变模式、剥离机制、粘合剂性能（即，粘性、剪切和剥离粘附力）以及体外生物制药性能（即，药物释放和皮肤渗透性）。线性和非线性流变学性质之间的关系和制备的贴剂的主要粘合剂和生物制药性能已被证明。基质的粘性组分越高，其内聚性越低，药物释放速率越快。布洛芬的体外皮肤渗透性不受聚合物基质的限制，即使与商业参考产品相比。总之，SEBS共聚物是设计药物粘附贴片的合适材料。特别是，SEBS-低分子量是值得考虑的聚合物，因为其有利的粘弹性行为。
Styrene-block-(ethylene-co-butylene)-block-styrene (SEBS) copolymers are biocompatible elastomers with outstanding stability to UV radiation. This work addresses the potentialities of this class of elastomers for the development of transdermal patches. The influence of SEBS molecular weight, plasticizer and tackifier type on rheological pattern, debonding mechanisms, adhesive properties (i.e., tack, shear and peel adhesion) as well as on the in vitro biopharmaceutical performances (i.e., drug release and skin permeability) was investigated using ibuprofen as model drug. The relationships between the linear and non-linear rheological properties and the main adhesive and biopharmaceutical properties of the prepared patches have been demonstrated. The higher the viscous component of the matrix, the lower its cohesiveness and the faster the drug release rate. The in vitro skin permeability of ibuprofen was not limited by the polymeric matrix, even if compared to the commercial reference product. In conclusion, SEBS copolymers are suitable materials to design drug in-adhesive patches. In particular, SEBS-low molecular weight is the polymer worthy of consideration because of its favorable viscoelastic behavior.