High-b-Value Diffusion-Weighted Imaging at 3 T to Detect Prostate Cancer: Comparisons Between b Values of 1,000 and 2,000 s/mm2
High-b-Value Diffusion-Weighted Imaging at 3 T to Detect Prostate Cancer: Comparisons Between b Values of 1,000 and 2,000 s/mm2
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DOI：
10.2214/ajr.09.3004
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发表时间：
2010-01-01
影响因子：
5
通讯作者：
Kim, Bohyun
中科院分区：
文献类型：
--
作者：
Kim, Chan Kyo;Park, Byung Kwan;Kim, Bohyun
目标。本研究的目的是探讨高b值扩散加权成像(1,000和2,000 S/mm(2))和相控阵线圈对前列腺癌的诊断价值。48例患者接受了3T单次激发回波平面弥散加权成像，然后行前列腺癌根治术。在高b值1,000和2,000 S/mm(2)下进行弥散加权成像。对周围区和移行区的肿瘤和良性组织的表观弥散系数(ADC)图进行视觉和定量评估。结果：b值为1,000和2,000 S/mm(2)的ADC图预测前列腺癌的灵敏度分别为88%和71%，准确率分别为89%和86%(P<；0.01)。在b值为1,000和2,000 S/mm(2)的情况下，肿瘤周围和移行区的平均ADC值均显著低于良性组织(p<；0.001)。结论：高b值的3T前列腺弥散加权像能提高肿瘤与良性组织的鉴别能力。在预测局限性前列腺癌方面，b值为1,000 S/mm(2)的弥散加权成像比b值为2,000 S/mm(2)的弥散加权成像更敏感和准确。
OBJECTIVE. The objective of our study was to investigate the diagnostic performance of 3-T MRI of the prostate using diffusion-weighted imaging (DWI) with high b values (1,000 and 2,000 s/mm(2)) and a phased-array coil in predicting localized prostate cancer.MATERIALS AND METHODS. Forty-eight patients underwent single-shot echo-planar DWI at 3 T, followed by radical prostatectomy. DWI was performed at high b values of 1,000 and 2,000 s/mm(2). Apparent diffusion coefficient (ADC) maps were analyzed by visual and quantitative assessment for tumor and benign tissue in the peripheral and transition zones. The visual and quantitative results of ADC maps obtained at b values of 1,000 and 2,000 s/mm(2) were compared with the histopathologic findings.RESULTS. To predict localized prostate cancer, the sensitivity of ADC maps obtained at a b value of 1,000 versus 2,000 s/mm(2) was 88% and 71%, respectively, and the accuracy was 89% and 86% (p < 0.01). The mean ADC values of tumors in both the peripheral and transition zones were significantly lower than those of benign tissues at both b values of 1,000 and 2,000 s/mm(2) (p < 0.001).CONCLUSION. Prostate DWI performed at 3 T using high b values was able to improve differentiation of tumors from benign tissue. DWI performed using a b value of 1,000 s/mm(2) was more sensitive and more accurate in predicting localized prostate cancer than DWI performed using a b value of 2,000 s/mm(2).