Tertiary pentyl groups enhance salen titanium catalyst for highly enantioselective trimethylsilylcyanation of aldehydes.
Tertiary pentyl groups enhance salen titanium catalyst for highly enantioselective trimethylsilylcyanation of aldehydes.
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DOI：
10.1021/jo0161779
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发表时间：
2002-03
期刊：
影响因子：
--
通讯作者：
S. Liang;X. Bu
中科院分区：
文献类型：
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作者：
S. Liang;X. Bu
叔戊基被认为是高度有效的空间基团，当它们用于芳族醛的不对称氰化时，其可以增强Salen钛络合物的对映选择性。高ee（92-97%）已获得与几个醛底物。与其叔丁基类似物相比，已发现叔戊基改善了对映选择性，并且在某些情况下相当显着。
tert-Pentyl groups are recognized to be highly effective steric groups that can enhance enantioselectivity of salen titanium complexes when they are used in asymmetrical cyanation of aromatic aldehydes. High ee (92-97%) has been obtained with several aldehyde substrates. Compared to its tert-butyl analogue, the tert-pentyl group has been found to improve enantioselectivity and in some cases quite dramatically.