Granulomatous hypersensitivity to Schistosoma mansoni EGG antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation.
Granulomatous hypersensitivity to Schistosoma mansoni EGG antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation.
复制标题
人血吸虫病中对曼氏血吸虫 EGG 抗原的肉芽肿性超敏反应。
DOI：
10.1111/j.1365-3024.1994.tb00299.x
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发表时间：
1994
影响因子：
2.2
通讯作者：
Doughty,BL
中科院分区：
文献类型：
--
作者：
Goes,AM;Rezende,SA;Gazzinelli,G;Doughty,BL
已知洋地黄素（PG）调节免疫细胞功能并参与急性和慢性炎症反应的进展。利用曼氏血吸虫虫卵诱导的过敏性肉芽肿体外模型，我们阐明了免疫复合物（IC）在PG诱导和释放中的作用及其对肉芽肿发展的抑制作用。使用体外肉芽肿形成模型检查了对可溶性虫卵抗原（SEA）的超敏型肉芽肿反应。我们的研究结果表明，肉芽肿形成显着抑制了肉芽肿培养物IC，PGE 1，PGE 2，而PGF 2 α没有显着的效果。通过引入阻断肉芽肿形成抑制的抗PG抗体来实现PG功能的抑制。在该模型系统中，IC可能通过刺激单核细胞-巨噬细胞谱系释放抑制性介质来抑制肉芽肿形成的活性。我们的研究结果表明，野牡丹素E系列可能是重要的生成和维持抑制肉芽肿性炎症反应S。mansonieg抗原
The prostaglandins (PG) are known to regulate immune cell function(s) and participate in the progression of both acute and chronic inflammatory reactions. Using anin vitromodel ofSchistosoma mansoniegg‐induced hypersensitivity granulomas, we have delineated the role of immune complexes (IC) in the induction and release of PG and their inhibitory effects on granuloma development. The hypersensitivity‐type granuloma reaction to soluble egg antigen (SEA) was examined using a model ofin vitrogranuloma formation. Our results show that granuloma formation was dramatically suppressed by the addition to the granuloma cultures of IC, PGE1, PGE2, while PGF2alpha had no significant effect. The inhibition of the PG function was achieved by the introduction of anti‐PG antibodies that blocked suppression of granuloma formation. It appears in this model system that IC may inhibit the activity of granuloma formation by stimulating the monocyte‐macrophage lineage to release inhibitory mediators. Our results suggest that the prostaglandins E series may be important in the generation and maintenance of suppression of the granulomatous inflammatory response toS. mansoniegg antigens.