An overview of microRNAs.
An overview of microRNAs.
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DOI：
10.1016/j.addr.2015.05.001
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发表时间：
2015-06-29
影响因子：
16.1
通讯作者：
Hammond SM
中科院分区：
文献类型：
--
作者：
Hammond SM
20多年前第一个微小RNA（miRNA）的发现开创了分子生物学的新时代。目前在人类中发现了2000多种miRNAs，据信它们共同调节基因组中三分之一的基因。miRNAs与许多人类疾病有关，并被用作临床诊断和治疗靶点。本文综述了miRNA的生物合成途径、生物学作用和临床应用。
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches.