Bilateral olfactory sensory input enhances chemotaxis behavior
Bilateral olfactory sensory input enhances chemotaxis behavior
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DOI：
10.1038/nn2031
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发表时间：
2008-02-01
影响因子：
25
通讯作者：
Vosshall, Leslie B.
中科院分区：
文献类型：
--
作者：
Louis, Matthieu;Huber, Thomas;Vosshall, Leslie B.
双边感觉输入的神经比较对于视觉深度感知和空间声音的准确定位至关重要。所有动物，从单细胞原核生物到人类，都会根据环境化学刺激来调整自己的方向，但嗅觉中神经活动的空间整合的贡献仍不清楚。我们在果蝇幼虫中研究了这个问题。使用高分辨率行为分析，我们研究了头部左侧或右侧具有单个功能嗅觉神经元的幼虫的趋化行为，使我们能够检查单侧或双侧嗅觉输入。我们开发了新的光谱方法来创建稳定的气味梯度，并通过实验测量气味浓度。在这些受控环境中，我们观察到单个功能神经元提供了足够的信息来允许幼虫趋化。我们发现了更多证据表明，通过双边感官输入带来的信噪比的增加，导航的整体准确性得到了提高。
Neural comparisons of bilateral sensory inputs are essential for visual depth perception and accurate localization of sounds in space. All animals, from single-cell prokaryotes to humans, orient themselves in response to environmental chemical stimuli, but the contribution of spatial integration of neural activity in olfaction remains unclear. We investigated this problem in Drosophila melanogaster larvae. Using high-resolution behavioral analysis, we studied the chemotaxis behavior of larvae with a single functional olfactory neuron on either the left or right side of the head, allowing us to examine unilateral or bilateral olfactory input. We developed new spectroscopic methods to create stable odorant gradients in which odor concentrations were experimentally measured. In these controlled environments, we observed that a single functional neuron provided sufficient information to permit larval chemotaxis. We found additional evidence that the overall accuracy of navigation is enhanced by the increase in the signal-to-noise ratio conferred by bilateral sensory input.