Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique
Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique
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DOI：
10.1002/mrm.26693
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Wu, Holden H.
中科院分区：
文献类型：
--
作者：
Armstrong, Tess;Dregely, Isabel;Wu, Holden H.
目的非酒精性脂肪肝的诊断金标准是侵入性活检。无创笛卡尔 MRI 脂肪定量仍然仅限于屏气 (BH)。在这项工作中，开发了一种新型自由呼吸 3D 径向堆叠（FB 径向）肝脏脂肪定量技术，并在初步研究中进行了评估。方法在 3 特斯拉下对人体模型和健康受试者 (n=11) 进行成像。使用线性回归（相关系数和一致性系数 (c)）和 Bland-Altman 分析，将使用 FB 径向（有和没有扫描加速）确定的质子密度脂肪分数 (PDFF) 与 BH 单体素 MR 波谱 (SVS) 和 BH 3D 笛卡尔 MRI 进行比较。结果在体模中，PDFF 显示显着相关性 (>0.998，(c)>0.995) 和绝对平均值差异 0.999，(c)>0.998) 和绝对平均差异 0.986，(c)>0.985) 和绝对平均差异 0.996，(c)>0.995) 和绝对平均差异
PurposeThe diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, a novel free-breathing 3D stack-of-radial (FB radial) liver fat quantification technique is developed and evaluated in a preliminary study.MethodsPhantoms and healthy subjects (n=11) were imaged at 3 Tesla. The proton-density fat fraction (PDFF) determined using FB radial (with and without scan acceleration) was compared to BH single-voxel MR spectroscopy (SVS) and BH 3D Cartesian MRI using linear regression (correlation coefficient and concordance coefficient (c)) and Bland-Altman analysis.ResultsIn phantoms, PDFF showed significant correlation (>0.998, (c)>0.995) and absolute mean differences0.999, (c)>0.998) and absolute mean differences 0.986, (c)>0.985) and absolute mean differences0.996, (c)>0.995) and absolute mean differences