Linguistic correlates of asymmetric motor symptom severity in Parkinson's Disease.
Linguistic correlates of asymmetric motor symptom severity in Parkinson's Disease.
复制标题
帕金森病不对称运动症状严重程度的语言相关性。
DOI：
10.1016/j.bandc.2009.08.004
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发表时间：
2010
影响因子：
2.5
通讯作者：
Durso,Raymond
中科院分区：
文献类型：
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作者：
Holtgraves,Thomas;McNamara,Patrick;Cappaert,Kevin;Durso,Raymond
不对称运动严重程度在帕金森病（PD）中很常见，并提供了一种检查与该疾病相关的认知和语言缺陷的神经生物学机制的方法。在本研究中，PD参与者（N=31）的运动症状的不对称性进行了评估。与参与者的访谈进行了分析与语言调查和单词计数（LIWC）程序。语言复杂性的三个衡量标准-动词的比例，功能词的比例和句子长度-被发现受到症状不对称。更严重的左侧运动（因此更大的右半球功能障碍）与产生的动词，功能词和较短的句子显着减少。因此，在自然语言环境中，语言复杂性的产生与相对更多的右半球参与有关。这种影响的潜在神经生物学机制进行了讨论。
Asymmetric motor severity is common in Parkinson’s Disease (PD) and provides a method for examining the neurobiologic mechanisms underlying cognitive and linguistic deficits associated with the disorder. In the present research, PD participants (N=31) were assessed in terms of the asymmetry of their motor symptoms. Interviews with the participants were analyzed with the Linguistic Inquiry and Word Count (LIWC) program. Three measures of linguistic complexity – the proportion of verbs, proportion of function words, and sentence length – were found to be affected by symptom asymmetry. Greater left-side motor severity (and hence greater right-hemisphere dysfunction) was associated with the production of significantly fewer verbs, function words, and shorter sentences. Hence, the production of linguistic complexity in a natural language context was associated with relatively greater right hemisphere involvement. The potential neurobiological mechanisms underlying this effect are discussed.