Changes in the shape of the developing vertebrate nervous system analyzed experimentally, mathematically and by computer simulation.
Changes in the shape of the developing vertebrate nervous system analyzed experimentally, mathematically and by computer simulation.
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通过实验、数学和计算机模拟分析发育中的脊椎动物神经系统的形状变化。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
Richard Gordon
中科院分区：
文献类型：
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作者：
Antone G. Jacobson;Antone G. Jacobson;Richard Gordon;Richard Gordon
两种力量是必要的，足以使蝾螈的神经板从一个细胞厚的半球形细胞片转变为钥匙孔形状。这些力量是：（1）神经板表面的区域性程序性收缩（通过神经板细胞顶面的收缩和这些细胞垂直于板的伸长来实现）;和（2）由脊索或覆盖的神经板细胞在前后方向上的伸长引起的整个片的移位。计算机模拟和数学分析（“形态动力学”），以及对胚胎的实验和观察，被用来从这些力中推断神经板的形态发生。
Two forces are necessary and sufficient to produce the transformation of the newt neural plate from a hemispheric sheet of cells one cell thick to a keyhole shape. These forces are: (1) a regionally programmed shrinkage of the surface of the neural plate (accomplished by contraction of the apical surfaces of the neural plate cells and elongation of these cells perpendicular to the plate); and (2) displacement of the whole sheet caused by elongation of either the notochord or the overlying neural plate cells in the antero-posterior direction. A computer simulation and mathematical analysis ("morphodynamics"), together with experiments and observations on embryos, were used to deduce the morphogenesis of the neural plate from these forces.