Body-mass index and symptoms of gastroesophageal reflux in women
Body-mass index and symptoms of gastroesophageal reflux in women
复制标题
DOI：
10.1056/nejmoa054391
复制
发表时间：
2006-06-01
影响因子：
158.5
通讯作者：
Camargo, Carlos A., Jr.
中科院分区：
文献类型：
--
作者：
Jacobson, Brian C.;Somers, Samuel C.;Camargo, Carlos A., Jr.
背景：超重和肥胖者患胃食管反流病的风险增加。体重指数（BMI）--体重（千克）除以身高（米）的平方--与正常体重人群的胃食管反流病症状之间的关联尚未得到证实。方法：在2000年，我们使用了一个补充问卷来确定频率，严重程度，护士健康研究中随机选择的参与者中胃食管反流病症状的持续时间。根据1998年测量的BMI对女性进行分类后，我们使用逻辑回归模型研究BMI与胃食管反流病症状之间的关系。在完成调查问卷的10,545名妇女中，（答复率，86%），2310（22%）报告每周至少有一次症状，3419（有任何症状的人中的55%）描述他们的症状为中度。我们观察到BMI增加和频繁的反流症状之间存在剂量依赖关系（多变量P趋势
Background: Overweight and obese persons are at increased risk for gastroesophageal reflux disease. An association between body-mass index (BMI) -- the weight in kilograms divided by the square of the height in meters -- and symptoms of gastroesophageal reflux disease in persons of normal weight has not been demonstrated.Methods: In 2000, we used a supplemental questionnaire to determine the frequency, severity, and duration of symptoms of gastroesophageal reflux disease among randomly selected participants in the Nurses' Health Study. After categorizing women according to BMI as measured in 1998, we used logistic-regression models to study the association between BMI and symptoms of gastroesophageal reflux disease.Results: Of 10,545 women who completed the questionnaire (response rate, 86 percent), 2310 (22 percent) reported having symptoms at least once a week, and 3419 (55 percent of those who had any symptoms) described their symptoms as moderate in severity. We observed a dose-dependent relationship between increasing BMI and frequent reflux symptoms (multivariate P for trend