The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair.
The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair.
复制标题
DOI：
10.3389/fcell.2021.672935
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Sauer H
中科院分区：
文献类型：
--
作者：
Khosravi F;Ahmadvand N;Bellusci S;Sauer H
目前对心血管研究的关注反映了社会对工业化世界中与心脏有关的疾病的惊人发病率和死亡率的关注，特别是迫切需要通过更有效的治疗来对抗这些疾病。为了追求这些治疗方法，全面了解心脏生物学中多功能成纤维细胞生长因子（FGF）信号传导的作用机制是非常重要的。FGF在心脏发育中的作用范围从流出道形成到心肌细胞的增殖和心腔的形成。在心脏再生的背景下，FGF 1、2、9、16、19和21介导适应性反应，包括心肌梗死后心脏收缩率的恢复和心肌梗死面积的减小。然而，人类疾病中的心脏并发症与FGF配体和/或FGF信号传导障碍的致病作用相关。FGF 2和23参与适应不良反应，如心脏肥大、纤维化反应和心力衰竭。在已知在心脏疾病中具有致病作用（FGF 2、21和23）或保护作用（FGF 2、15/19、16和21）的FGF中，FGF 15/19、21和23显示出诊断潜力。FGF在发育过程中诱导祖干细胞分化为心肌细胞的有效作用已被用于增强出生后心脏修复的有限能力。为了更新或补充受损的心肌细胞，在基于（诱导）多能干细胞的方法中测试FGF 1、2、10和16，并用于刺激成年心肌细胞中的细胞周期再进入。本文综述了FGF配体及其受体在心脏中介导的多种有益和有害作用，这可能为改善心脏并发症开辟新的治疗途径。
The current focus on cardiovascular research reflects society’s concerns regarding the alarming incidence of cardiac-related diseases and mortality in the industrialized world and, notably, an urgent need to combat them by more efficient therapies. To pursue these therapeutic approaches, a comprehensive understanding of the mechanism of action for multifunctional fibroblast growth factor (FGF) signaling in the biology of the heart is a matter of high importance. The roles of FGFs in heart development range from outflow tract formation to the proliferation of cardiomyocytes and the formation of heart chambers. In the context of cardiac regeneration, FGFs 1, 2, 9, 16, 19, and 21 mediate adaptive responses including restoration of cardiac contracting rate after myocardial infarction and reduction of myocardial infarct size. However, cardiac complications in human diseases are correlated with pathogenic effects of FGF ligands and/or FGF signaling impairment. FGFs 2 and 23 are involved in maladaptive responses such as cardiac hypertrophic, fibrotic responses and heart failure. Among FGFs with known causative (FGFs 2, 21, and 23) or protective (FGFs 2, 15/19, 16, and 21) roles in cardiac diseases, FGFs 15/19, 21, and 23 display diagnostic potential. The effective role of FGFs on the induction of progenitor stem cells to cardiac cells during development has been employed to boost the limited capacity of postnatal cardiac repair. To renew or replenish damaged cardiomyocytes, FGFs 1, 2, 10, and 16 were tested in (induced-) pluripotent stem cell-based approaches and for stimulation of cell cycle re-entry in adult cardiomyocytes. This review will shed light on the wide range of beneficiary and detrimental actions mediated by FGF ligands and their receptors in the heart, which may open new therapeutic avenues for ameliorating cardiac complications.
登录
查看更多内容
影响因子：
6.1
作者：
Andersen, Ingrid A.;Huntley, Brenda K.;Burnett, John C., Jr.
通讯作者：
Burnett, John C., Jr.
影响因子：
13.6
作者：
Doroudgar S;Glembotski CC
通讯作者：
Glembotski CC
影响因子：
7.3
作者：
Chao, Cho-Ming;Yahya, Faady;Moiseenko, Alena;Tiozzo, Caterina;Shrestha, Amit;Ahmadvand, Negah;El Agha, Elie;Quantius, Jennifer;Dilai, Salma;Kheirollahi, Vahid;Jones, Matthew;Wilhem, Jochen;Carraro, Gianni;Ehrhardt, Harald;Zimmer, Klaus-Peter;Barreto, Guillermo;Ahlbrecht, Katrin;Morty, Rory E.;Herold, Susanne;Abellar, Rosanna G.;Seeger, Werner;Schermuly, Ralph;Zhang, Jin-San;Minoo, Parviz;Bellusci, Saverio
通讯作者：
Bellusci, Saverio
影响因子：
39.3
作者：
Chua, Winnie;Purmah, Yanish;Fabritz, Larissa
通讯作者：
Fabritz, Larissa
影响因子：
2.7
作者：
Chen C;Meng Z;Zheng Y;Hu B;Shen E
通讯作者：
Shen E