The effect of prolonged physical training on the properties of long bone: a study of Wolff's Law.
The effect of prolonged physical training on the properties of long bone: a study of Wolff's Law.
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长时间体能训练对长骨特性的影响：沃尔夫定律的研究。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
W. Akeson
中科院分区：
文献类型：
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作者：
S. Woo;S. Kuei;D. Amiel;M. Gómez;W. Hayes;F. White;W. Akeson
未标记
五个一岁大的未成熟的猪进行了12个月的运动训练。四只没有训练的匹配猪作为对照。它们被杀死后，从股骨中央骨干的前、内、后和外侧象限取出四毫米宽的骨条，进行四点弯曲测试直至失效。结果发现，虽然运动并没有改变皮质骨的机械性能，但它导致股骨平均横截面性能显著增加：皮质厚度增加17%，皮质横截面积增加23%，最大和最小面积惯性矩分别增加21%和27%。这些变化主要是由于髓管直径减小所致。骨成分分析表明，对照组和运动组动物的骨密度和生化含量相似，但总体积和干重，灰分和钙的重量显着较高的运动骨。这些综合结果表明，长时间运动对骨骼的数量有显著影响，但对其质量没有影响。
临床相关性
长期以来，人们已经认识到，石膏模型中固定的应力剥夺导致严重的骨萎缩，并且普遍认为最低水平的活动对于骨的稳态是必要的。这些结果表明，与人类跑步健身计划中规定的水平相当的运动（最大心率的65%至80%）不仅可以保持体内平衡，而且可以产生实际的骨骼肥大。这项工作进一步表明，在克服精神分裂症的国家的重要性，渐进的，长期的，监督康复计划。
UNLABELLED
Five one-year-old immature swine were subjected to twelve months of exercise training. Four matched swine with no training served as controls. After they were killed, four-millimeter-wide strips of bone taken from the anterior, medial, posterior, and lateral quadrants of the central femoral diaphysis were subjected to four-point bending tests to failure. It was found that although exercise did not change the mechanical properties of the cortical bone, it resulted in significant increases in the averaged femoral cross-sectional properties: 17 per cent in cortical thickness, 23 per cent in cortical cross-sectional area, and 21 per cent and 27 per cent in maximum and minimum area moments of inertia, respectively. These changes were due primarily to reduction in the diameter of the medullary canal. The analyses of bone composition showed that the bone density and biochemical contents of the control and exercised animals were similar, but the total volume and the dry, ash, and calcium weights of the exercised bone were significantly higher. These combined results suggest that prolonged exercise has a significant effect on the quantity of the bone, but not on its quality.
CLINICAL RELEVANCE
It has long been recognized that stress deprivation from immobilization in plaster casts results in profound bone atrophy, and it is generally accepted that a minimum level of activity is necessary for homeostasis of bone. These results show that exercise at a level comparable to that prescribed in running fitness programs for humans (65 to 80 per cent of maximum heart rate) can not only maintain homeostasis, but produce actual hypertrophy of bone. This work further suggests the importance of graduated, prolonged, supervised rehabilitation programs in overcoming osteoporotic states.