Magnesium Deficiency in Patients on Long-Term Diuretic Therapy for Heart Failure
Magnesium Deficiency in Patients on Long-Term Diuretic Therapy for Heart Failure
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DOI：
10.1136/bmj.3.5827.620
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发表时间：
1972-09
影响因子：
--
通讯作者：
P. Lim;E. Jacob
中科院分区：
文献类型：
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作者：
P. Lim;E. Jacob
对10例因心力衰竭接受利尿剂治疗平均3·3年的瓣膜性心脏病患者的血清、红细胞、骨骼肌和骨中镁水平进行了测定。发现五名患者的骨骼肌值下降，表明镁严重缺乏。5名患者中只有2名红细胞值较低，血清超滤液和骨均无低值：镁替代治疗使骨骼肌值恢复正常。在所有五名镁缺乏患者中发现了与镁缺乏症存在一致的临床特征。除少数例外情况外，这些特征通过镁置换得到纠正。后者还纠正了所有5例低骨骼肌镁患者中存在的低骨骼肌钾值，其中4例在给予镁治疗前表现出地高辛中毒的临床特征。伴随继发性醛固酮增多症、饮食摄入不足和地高辛治疗可能增加了利尿剂治疗引起的镁丢失。
Magnesium levels in serum, erythrocytes, skeletal muscle, and bone were measured in 10 patients with valvular heart disease who had received diuretic therapy for heart failure for an average of 3·3 years. Five patients were found to have diminished values for skeletal muscle, indicating significant magnesium deficit. Values for erythrocytes were low in only two of the five patients, and none had low values for serum ultrafiltrate and bone: Magnesium replacement therapy restored skeletal muscle values to normal. Clinical features consistent with the presence of magnesium deficiency were found in all five magnesium-deficient patients. These features were, with few exceptions, corrected by magnesium replacement. The latter also corrected low skeletal muscle potassium values present in all five patients with low skeletal muscle magnesium, four of whom showed clinical features of digoxin poisoning before magnesium therapy was given. Concomitant secondary aldosteronism, inadequate dietary intake, and digoxin therapy had probably augmented the magnesium loss due to diuretic therapy.