Murine Cecal Patch M Cells Transport Infectious Prions In Vivo
Murine Cecal Patch M Cells Transport Infectious Prions In Vivo
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DOI：
10.1086/657415
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发表时间：
2010-12-15
影响因子：
6.4
通讯作者：
Macpherson, Gordon G.
中科院分区：
文献类型：
--
作者：
Foster, Neil;Macpherson, Gordon G.
我们表明，口服接种后，朊病毒结合回肠派尔集合淋巴结和盲肠集合淋巴结微折叠细胞（M细胞）在体内。此外，我们的证据表明，盲肠作为一个生物水池举行高浓度的朊病毒相对较长的时间，从而增加盲肠补丁M细胞的暴露时间。我们的研究结果显示了朊病毒从哺乳动物体内肠腔易位的关键初始步骤，这是感染的前兆。
We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.