Cooling the area postrema induces conditioned taste aversions in male rats and blocks acquisition of LiCl-induced aversions.
Cooling the area postrema induces conditioned taste aversions in male rats and blocks acquisition of LiCl-induced aversions.
复制标题
冷却后部区域会引起雄性大鼠条件性味觉厌恶，并阻止获得氯化锂引起的厌恶。
DOI：
10.1037//0735-7044.111.4.768
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发表时间：
1997
影响因子：
1.9
通讯作者：
Chambers,KC
中科院分区：
文献类型：
--
作者：
Wang,Y;Lavond,DG;Chambers,KC
在这篇文章中提出的实验的目的是检查是否最后区（AP）病变减弱氯化锂诱导的条件性味觉厌恶（CTA）的信息中断的疾病产生的属性的氯化锂或病变引起的不适。冷却引起的AP可逆性损伤诱导雄性大鼠CTA。如果雄性在采集日之前暴露于冷却几天，则冷却诱导的CTA可以被阻断。如果雄性动物在采集日之前和采集日的LiCl给药期间暴露于冷却，则其LiCl诱导CTA的采集被阻断;如果雄性动物仅在采集日之前暴露于冷却，则其CTA采集减弱但未被阻断;如果雄性动物仅在LiCl给药期间暴露于冷却，则其CTA采集未发生变化。总之，这些结果表明，AP是重要的收购氯化锂诱导的CTA，但该地区的失活是如此令人厌恶，它会诱导CTA，可以掩盖衰减氯化锂诱导的厌恶。
The experiments presented in this article were designed to examine whether area postrema (AP) lesions attenuate LiCl-induced conditioned taste aversions (CTAs) by disruption of information about the illness-producing properties of LiCl or by a lesion-induced malaise. Reversible lesioning of the AP caused by cooling induced a CTA in male rats. The cooling-induced CTA could be blocked if males were exposed to cooling for several days before acquisition day. Acquisition of a LiCl-induced CTA was blocked in males if they were exposed to cooling before acquisition day and during LiCl administration on acquisition day, was attenuated but not blocked in males if they were exposed to cooling only before acquisition day, and was unchanged in males if they were exposed to cooling only during LiCl administration. Taken together these results indicate that the AP is important for acquisition of LiCl-induced CTAs but that inactivation of this area is so aversive it will induce CTAs that can obscure the attenuation of LiCl-induced aversions.