Growing functions of the ESCRT machinery in cell biology and viral replication.

Growing functions of the ESCRT machinery in cell biology and viral replication.
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ESCRT 机器在细胞生物学和病毒复制中的功能不断增强。

DOI:
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发表时间:
2017
影响因子:
3.9
通讯作者:
J. Martin
J. Martin
中科院分区:
生物学3区
文献类型:
--
作者:
E. Scourfield;J. Martin

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近年来,由转运所需的内体分选复合物(ESCRT)机制促进的细胞过程的巨大扩展加强了其作为模块化系统的身份,该模块化系统使用多个衔接子在不同的细胞内位点募集核心膜重塑活性并促进膜断裂。与极光B依赖的发射检查点等过程的功能连接也突出了ESCRT机制的时空调节的重要性。在这里,我们总结了ESCRT在病毒出芽中的作用,以及我们从研究这一过程中了解到的ESCRT途径。这些进展进行了讨论的背景下,已被改造的ESCRT领域的研究,包括细胞动力学的分裂,核膜resealing和质膜修复的细胞生物学领域。
The vast expansion in recent years of the cellular processes promoted by the endosomal sorting complex required for transport (ESCRT) machinery has reinforced its identity as a modular system that uses multiple adaptors to recruit the core membrane remodelling activity at different intracellular sites and facilitate membrane scission. Functional connections to processes such as the aurora B-dependent abscission checkpoint also highlight the importance of the spatiotemporal regulation of the ESCRT machinery. Here, we summarise the role of ESCRTs in viral budding, and what we have learned about the ESCRT pathway from studying this process. These advances are discussed in the context of areas of cell biology that have been transformed by research in the ESCRT field, including cytokinetic abscission, nuclear envelope resealing and plasma membrane repair.
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