Persistent hot flushes in older postmenopausal women
Persistent hot flushes in older postmenopausal women
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DOI：
10.1001/archinte.168.8.840
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发表时间：
2008-04-28
影响因子：
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通讯作者：
Sawaya, George F.
中科院分区：
文献类型：
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作者：
Huang, Alison J.;Grady, Deborah;Sawaya, George F.
目的：探讨老年绝经后妇女潮热的患病率、自然史和预测因素，对3167例老年绝经后骨质疏松妇女潮热的患病率、严重程度和3年内潮热严重程度的变化进行问卷调查。Logistic回归被用来确定基线和3年后的随访症状相关的特征。结果：在基线，375名妇女（11.8%）报告令人烦恼的潮热。受教育程度较低的女性更容易出现基线症状（比值比[ OR]，1.28; 95%置信区间[CI]，每4年下降1.06-1.53），最近绝经（OR，1.44; 95% CI，每5年下降1.34-1.56），既往使用过雌激素（OR，1.57; 95% CI，1.23-2.00），或曾使用过。子宫切除术（OR，1.51; 95%CI，1.14-1.99）。潮热还与较高的体重指数（OR，1.22; 95%CI，1.08-1.38/SD）、较高的促卵泡激素水平（OR，1.34; 95%CI，1.20- 1.38/SD）相关。51/I SD），降低高密度脂蛋白水平（OR，1。17; 95%CI，每1 SD减少1.03-1.34）、阴道干燥（OR，1.52; 95%CI，1.19-1.93）和睡眠困难（OR，2.48; 95% CI，1.94-3.16），但雌二醇水平无变化。在375名有基线症状的女性中，278名提供了3年的数据，其中157名（56.5%）女性在3年后报告了持续的症状。绝经年限减少（OR，1.15; 95% CI，每5年减少1.01-1.32）和睡眠障碍（OR，1.97; 95% CI，1.01 - 1.32）。19-3.26）与症状持续性有关。结论：对于相当一部分女性来说，潮热是绝经后期不适的持续来源。确定潮热的危险因素可能有助于指导该人群的评估和治疗。
Objective: To examine the prevalence, natural history, and predictors of hot flushes in older postmenopausal women.Methods:.Prevalence, severity, and 3-year change in severity of hot flushes were assessed by questionnaire in 3167 older postmenopausal women with osteoporosis. Logistic regression was used to identify characteristics associated with symptoms at baseline and after 3 years of follow-up.Results: At baseline, 375 women (11.8%) reported bothersome hot flushes. Women were more likely to have baseline symptoms if they were less educated (odds ratio [ OR], 1.28; 95% confidence interval [CI], 1.06-1.53 per 4-year decrease), more recently menopausal (OR, 1.44; 95% Cl, 1.34-1.56 per 5-year decrease), had previously used estrogen (OR, 1.57; 95% Cl, 1.23-2.00), or had. undergone hysterectomy (OR, 1.51; 95% Cl, 1.14-1.99). Hot flushes were also associated with higher body rnass index (OR, 1.22; 95% Cl, 1.08-1.38 per 1 SD) higher follicle-stimulating hormone levels (OR, 1.34; 95% Cl, 1.20-1. 51 per I SD), lower high-density lipoprotein levels (OR, 1. 17; 95% Cl, 1.03-1.34 per 1SD decrease), vaginal dryness (OR, 1.52; 95% Cl, 1.19-1.93), and trouble sleeping (OR., 2.48; 95% Cl, 1.94-3.16), but not estradiol levels. Of the 375 women with baseline symptoms, 278 contributed 3-year data, and 157 (56.5%) of these women reported persistent symptoms after 3 years. Fewer years since menopause (OR, 1.15; 95% Cl, 1.01-1.32 per 5-year decrease) and trouble sleeping (OR, 1.97; 95% Cl, 1. 19-3.26) were associated with symptom persistence.Conclusions: For a substantial minority of women, hot flushes are a persistent source of discomfort into the late postmenopausal years. Identification of risk factors for hot flushes may help guide evaluation and treatment in this population.