Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry
Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry
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DOI：
10.1021/jasms.0c00004
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发表时间：
2020-03-01
影响因子：
3.2
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
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作者：
Fedick, Patrick W.;Pu, Fan;Cooks, R. Graham
芬太尼及其类似物在目前的阿片类药物流行中发挥着重要作用。特别是，这些强效阿片类药物由于被用作街头毒品的添加剂，已成为一种健康危害。因此，需要对这类缉获药物进行快速现场分析，特别是考虑到所报告的药物样品积压，这些样品必须经过鉴定和确认测试，以证实是否存在非法物质。纸基装置是廉价的取样和分析工具，已证明能够快速识别和确认滥用药物。通过压印纳米颗粒对纸基材进行改性使得能够进行表面增强拉曼光谱（Sers）以及来自相同基材的第二分析，即纸喷雾电离质谱。虽然这种程序是为实验室使用而描述的，但这些非法药物样本通常是在实地收集的，应该在实地进行检测。我们将联合收割机纸Sers和纸喷雾MS结合在现场便携式和商业现货（COTS）设备上，用于快速和低成本地识别和确认芬太尼及其类似物，从而能够在扣押可疑样品时进行原位分析。这两种仪器的商业性质将这项技术从学术领域转移到刑事司法系统可以实际使用它的环境中。通过对各种法医感兴趣的表面进行采样，进一步检查这种单基质双分析仪技术的能力。
Fentanyl and its analogues play a major role in the current opioid epidemic. In particular, these highly potent opioids have become a health hazard due to their use as additives in street drugs. Consequently, rapid on-site procedures for the analysis of this class of seized drugs are needed, especially considering the reported backlog of drug samples, which must undergo identification and confirmation tests to validate the presence of an illicit substance. Paper based devices are cheap sampling and analysis vehicles that have been shown capable of allowing rapid identification and confirmation of drugs of abuse. Modifying paper substrates by imprinting nanoparticles enables surface enhanced Raman spectroscopy (SERS) as well as a second analysis from the same substrate, namely paper spray ionization mass spectrometry. While such a procedure has been described for laboratory use, these illicit drug samples are typically collected in the field and this is where testing should be done. We combine paper SERS and paper spray MS on field-portable and commercial off-the-shelf (COTS) devices for the rapid and low-cost identification and confirmation of fentanyl and its analogues, enabling in situ analysis at the point of seizure of suspect samples. The commercial nature of both instruments moves this technology from the academic realm to a setting where the criminal justice system can realistically utilize it. The capabilities of this single-substrate dual-analyzer technique are further examined by sampling a variety of surfaces of forensic interest.