Childhood thyroid cancer in Belarus, Russia, and Ukraine after Chernobyl and at present
Childhood thyroid cancer in Belarus, Russia, and Ukraine after Chernobyl and at present
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DOI：
10.1590/s0004-27302007000500012
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发表时间：
2007-07-01
期刊：
影响因子：
--
通讯作者：
Yamashita, Shunichi
中科院分区：
文献类型：
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作者：
Demidchik, Yuri E.;Saenko, Vladimir A.;Yamashita, Shunichi
儿童甲状腺癌通常很少见，但在暴露于辐射的个体中，患病的风险会大大增加。1986年切尔诺贝利事故发生后，大约十年后，甲状腺癌发病率最大上升了10倍以上，累积导致生活在白俄罗斯、俄罗斯和乌克兰领土上的受放射性尘埃影响的儿童中新诊断的病例超过1000例。疫情的经验极大地促进了儿科临床肿瘤学、病理学和基础科学方面的知识。本文综述了儿童切尔诺贝利放射性甲状腺癌的流行病学、临床特点、治疗结果及随访情况，并与目前诊断的散发性病例进行了比较。此外，我们还讨论了儿童甲状腺癌的一般病理和分子表现。
Thyroid cancer in children is usually rare, but in the individuals exposed to radiation risk of disease increases considerably. After the Chernobyl accident in 1986, an over 10-fold maximal elevation in the incidence of thyroid cancer was registered about a decade later, cumulatively resulting in more than a thousand of newly diagnosed cases in children who lived in the territories of Belarus, Russia, and Ukraine affected by radioactive fallouts. Experience from the epidemic substantially promoted knowledge in clinical pediatric oncology, pathology and basic sciences. This article overviews epidemiology, clinical features, results of treatment and follow-up of childhood patients with radiation-induced Chernobyl thyroid cancer in comparison to sporadic cases diagnosed at present. In addition, we discuss general issues of pathology and molecular findings in childhood thyroid carcinomas.