Intrinsic functional architecture of the macaque dorsal and ventral lateral frontal cortex
Intrinsic functional architecture of the macaque dorsal and ventral lateral frontal cortex
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DOI：
10.1152/jn.00486.2016
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发表时间：
2017-03-01
影响因子：
2.5
通讯作者：
Margulies, Daniel S.
中科院分区：
文献类型：
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作者：
Goulas, Alexandros;Stiers, Peter;Margulies, Daniel S.
猕猴外侧额叶皮层（LFC）的细胞和连接组织的调查提供了必不可少的知识，产生关于人类LFC的假说。然而，尽管进行了大量的研究，但对这一大脑区域的组织仍存在争议。体内神经成像技术，如静息态功能性磁共振成像（fMRI），可用于定义脑区的功能回路，产生的结果在很大程度上与金标准侵入性追踪技术一致，并提供了在同一模式下进行跨物种比较的机会。我们的研究结果使用猕猴的静息态fMRI来揭示LFC的内在功能结构，证实了以前的研究结果，并为当前的争论提供了信息。具体地说，在背侧LFC内，我们发现：1）沿着中线和上级弓状沟前方的区域沿着被分为两个区域，由后主上凹分开，2）细胞结构定义的区域6DC/F2包含两个连接分区，和3）一个独特的区域占据弓状沟骨刺周围的皮质，更新了先前提出的背侧和腹侧运动/前运动区之间的边界。在腹侧LFC内，导出的分割清楚地表明存在不同的区域：1）具有躯体运动/口面连接特征的区域（推定的区域44），2）具有眼神经连接特征的区域（推定的额眼区域），以及3）可能承载喉和臂表征的运动前区。我们的研究结果详细说明了猕猴LFC的内在功能架构，从而提供了有价值的证据辩论其organization.NEW &值得注意的静息态功能磁共振成像是作为一种补充的方法，侵入性技术，以告知当前的辩论猕猴外侧额叶皮层的组织。鉴于猕猴皮层作为人类皮层的模型，我们的研究结果有助于为人类外侧额叶皮层的组织产生更精细的假设。
Investigations of the cellular and connectional organization of the lateral frontal cortex (LFC) of the macaque monkey provide indispensable knowledge for generating hypotheses about the human LFC. However, despite numerous investigations, there are still debates on the organization of this brain region. In vivo neuroimaging techniques such as resting-state functional magnetic resonance imaging (fMRI) can be used to define the functional circuitry of brain areas, producing results largely consistent with gold-standard invasive tract-tracing techniques and offering the opportunity for cross-species comparisons within the same modality. Our results using resting-state fMRI from macaque monkeys to uncover the intrinsic functional architecture of the LFC corroborate previous findings and inform current debates. Specifically, within the dorsal LFC, we show that 1) the region along the midline and anterior to the superior arcuate sulcus is divided in two areas separated by the posterior supraprincipal dimple, 2) the cytoarchitectonically defined area 6DC/F2 contains two connectional divisions, and 3) a distinct area occupies the cortex around the spur of the arcuate sulcus, updating what was previously proposed to be the border between dorsal and ventral motor/premotor areas. Within the ventral LFC, the derived parcellation clearly suggests the presence of distinct areas: 1) an area with a somatomotor/orofacial connectional signature (putative area 44), 2) an area with an oculomotor connectional signature (putative frontal eye fields), and 3) premotor areas possibly hosting laryngeal and arm representations. Our results illustrate in detail the intrinsic functional architecture of the macaque LFC, thus providing valuable evidence for debates on its organization.NEW & NOTEWORTHY Resting-state functional MRI is used as a complementary method to invasive techniques to inform current debates on the organization of the macaque lateral frontal cortex. Given that the macaque cortex serves as a model for the human cortex, our results help generate more fine-tuned hypothesis for the organization of the human lateral frontal cortex.