Are techniques for general anesthesia less invasive than procedures for cataract surgery?
Are techniques for general anesthesia less invasive than procedures for cataract surgery?
复制标题
全身麻醉技术是否比白内障手术的侵入性更小？
作者：
Azma T;Nishioka A
我们同意Latasiewicz等人的结论1“羟氯喹视网膜病变：一个新出现的问题”，其中引用了羟氯喹（HCQ）诱导视网膜损伤的病例。3例患者每天服用400 mg HCQ超过15年（2例为4.93 mg/kg/天，1例为5.6 mg/kg/天），所有患者均发展为不同严重程度的黄斑病变。Latasiewicz等人的研究推荐了一种标准化的筛查方案来监测HCQ治疗患者的视网膜毒性。如前所述，不同剂量的HCQ的眼毒性范围从无明显的角膜病变到潜在的致盲性视网膜病变。2016年，美国眼科学会推荐HCQ每日最大使用量为5.0 mg/kg，基线基础检查以排除已有的黄斑病变，并在使用HCQ 5年后进行年度筛查。HCQ是一种合成抗疟药，用于自身免疫性疾病的免疫调节。2 HCQ的常用日剂量为200mg或400mg（相当于75kg患者的剂量分别为5.3 mg/kg和2.6 mg/kg），治疗性血浆浓度为500- 2000ng HCQ/ml。
We agreed with the conclusions of Latasiewicz et al1 ‘Hydroxychloroquine retinopathy: an emerging problem', which cited cases of hydroxychloroquine (HCQ)-induced retinal damage. Three patients had received 400 mg HCQ daily for over 15 years (equaling 4.93 mg/kg/day in two and 5.6 mg/kg/day in one) and all developed maculopathies of varying severity. The study by Latasiewicz et al1 recommended a standardized screening protocol to monitor for retinal toxicity in patients treated with HCQ. Ocular toxicity ranged from non-significant keratopathy to a potentially blinding retinopathy as described previously with varying doses of HCQ. 1, 2 In 2016 the American Academy of Ophthalmology recommended a maximum daily HCQ use of 5.0 mg/kg, a baseline fundal examination to exclude pre-existing maculopathy and an annual screening after 5 years of HCQ use. 3Being a synthetic antimalarial, HCQ is used for immunomodulation in autoimmune diseases. 2 Commonly used daily doses of HCQ are 200mg or 400 mg (which equals a dose of 5.3 mg/kg and 2.6 mg/kg for a 75 kg patient, respectively), and therapeutic plasma concentrations of 500-2000 ng HCQ/ml have previously been described.
直接口服抗凝药物（DOAC）。
影响因子：
2.8
作者：
R. Blum;Dan Lindfield
通讯作者：
Dan Lindfield
影响因子：
3.9
作者：
Alboim, C.;Kliemann, R. B.;Biolo, A.
通讯作者：
Biolo, A.