Left ventricular hypertrophy is more prevalent in blacks than whites in the general population - The Dallas Heart Study
Left ventricular hypertrophy is more prevalent in blacks than whites in the general population - The Dallas Heart Study
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DOI：
10.1161/01.hyp.0000169972.96201.8e
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发表时间：
2005-07-01
期刊：
影响因子：
8.3
通讯作者：
Victor, RG
中科院分区：
文献类型：
--
作者：
Drazner, MH;Dries, DL;Victor, RG
尽管最近的研究表明，与白人相比，黑人左心室肥大的患病率更高，但尽管调整了身体成分（脂肪质量和无脂肪质量），并在普通人群中进行心脏MRI评估，但仍不确定这是否属实。达拉斯心脏研究是一项在达拉斯县开展的基于人群的研究，其中1335名黑人和858名白色参与者（年龄在30至67岁之间）接受了详细评估，包括双能X线吸收测定扫描以测量身体成分和心脏MRI。左心室肥大，无论是通过体表面积指数（P < 0.001）、无脂肪质量（P = 0.002）还是身高（2.7）（P < 0.001）来定义，黑人女性的发生率是白色女性的2至3倍。当比较黑人和白色男性时，观察到类似的结果（当左心室肥大指数为体表面积或身高（2.7）时，P < 0.001，当指数为无脂肪质量时，P = 0.05）。在多变量模型中，尽管校正了脂肪量、无脂肪量、收缩压、年龄、性别和社会经济地位的测量，左心室质量的种族差异仍然存在。我们的结论是，与白人相比，黑人的左心室质量增加，左心室肥大的患病率在一般人群中高2至3倍，心脏MRI评估。左心室质量的种族差异与身体成分的差异无关。
Although recent studies have suggested that blacks compared with whites have an increased prevalence of left ventricular hypertrophy, it remains uncertain whether this is true despite adjustment for body composition ( fat mass and fat-free mass) and when assessed by cardiac MRI in the general population. The Dallas Heart Study is a population-based study of Dallas County in which 1335 black and 858 white participants 30 to 67 years of age underwent detailed assessment including dual-energy x-ray absorptiometry scan to measure body composition and cardiac MRI. Left ventricular hypertrophy, whether defined by indexation to body surface area ( P < 0.001), fat-free mass ( P = 0.002), or height(2.7) ( P < 0.001) was 2- to 3-fold more common in black versus white women. Similar results were seen when comparing black and white men ( P < 0.001 when left ventricular hypertrophy was indexed to body surface area or height(2.7) and P = 0.05 when indexed to fat-free mass). Ethnic disparities in left ventricular mass persisted in multivariable models despite adjustment for fat mass, fat-free mass, systolic blood pressure, age, gender, and measures of socioeconomic status. We conclude that blacks compared with whites have increased left ventricular mass and a 2- to 3-fold higher prevalence of left ventricular hypertrophy in the general population, as assessed by cardiac MRI. The ethnic differences in left ventricular mass are independent of differences in body composition.