Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes
Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes
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DOI：
10.1042/0264-6021:3530169
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发表时间：
2001-01-15
影响因子：
4.1
通讯作者：
Richter, W
中科院分区：
文献类型：
--
作者：
Steck, E;Benz, K;Richter, W
在寻找适合区分培养物中的软骨细胞与成骨细胞和间充质干细胞的新标记基因的过程中，我们鉴定并表征了一种称为软骨细胞表达蛋白-68（CEP-68）的新基因，该基因含有 N 末端前导肽和表皮生长因子样钙结合结构域。 CEP-68 定义了一个新的蛋白质家族，并补充了 II 型胶原蛋白，作为基于干细胞的软骨形成组织工程的新标记。
In the search for new marker genes suitable to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture, we have identified and characterized a novel gene called chondrocyte expressed protein-68 (CEP-68), harbouring an N-terminal leader peptide and an epidermal growth factor-like calcium-binding domain. CEP-68 defines a new family of proteins and complements collagen type II as a new marker for stem-cell-based chondrogenic tissue engineering.