Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea
Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea
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牛角瓜叶的植物化学和细胞毒性研究
DOI：
10.1016/j.bmcl.2017.04.087
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Nguyen N.T.
中科院分区：
文献类型：
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作者：
Nguyen K.D.H.;Dang P.H.;Nguyen H.X.;Nguyen M.T.T.;Awale S.;Nguyen N.T.
从马蹄莲叶的活性组分CHCl 3（IC 50，0.32 μg mL−1）和EtOAc（IC 50，0.55 μg mL−1）中分离得到一个新的木脂素9′-甲氧基辛烯醇（1）和两个新的糖基化5-羟甲基糠醛，calofurfumalside A（2）和calofurfumalside B（3），以及9个已知化合物（4-12）。其结构经NMR和MS确证。其中化合物1和9在正常血糖条件下对人胰腺癌细胞株PANC-1具有较强的细胞毒活性，IC 50值分别为3.7和3.3 μM。9′-甲氧频哪醇（1）可明显抑制PANC-1细胞的殖民地形成，并呈浓度依赖性。
A new lignan, 9′-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4–12) have been isolated from the active fractions, CHCl3(IC50, 0.32 μg mL−1) and EtOAc (IC50, 0.55 μg mL−1) fractions of the leaves ofCalotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds1and9exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC50values of 3.7 and 3.3 μM, respectively. 9′-Methoxypinoresinol (1) significantly inhibited the colony formation of PANC-1 cells in a concentration-dependent manner.