Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder.
Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder.
复制标题
DOI：
10.1109/embc46164.2021.9630273
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
脑深部电刺激（DBS）有望治疗越来越多的神经和精神疾病。DBS结果直接是相关脑结构的最佳靶向因素。计算模型可以通过预测DBS电极触点周围的激活组织（VTA）体积来帮助解释患者的结果。在这里，我们报告的DBS在两名强迫症患者的初步研究结果，并显示VTA预测，这是基于患者特定的体积导体模型，与临床结果相关。我们的研究结果表明，患者特定的VTA计算可以帮助通知设备编程，以最大限度地提高治疗效果和最大限度地减少副作用。
Deep brain stimulation (DBS) promises to treat an increasing number of neurological and psychiatric disorders. DBS outcome is directly a factor of optimal targeting of the relevant brain structures. Computational models can help to interpret a patient’s outcome by predicting the volume of tissue activated (VTA) around DBS electrode contacts. Here we report results of a preliminary study of DBS in two patients with obsessive-compulsive disorder and show that VTA predictions, which are based on patient-specific volume conductor models, correlate with clinical outcome. Our results suggest that patient specific VTA calculation can help inform device programing to maximize therapeutic effects and minimize side effects.