Murine Models of Heart Failure with Preserved Ejection Fraction: a "Fishing Expedition".
Murine Models of Heart Failure with Preserved Ejection Fraction: a "Fishing Expedition".
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DOI：
10.1016/j.jacbts.2017.07.013
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Sam F
中科院分区：
文献类型：
--
作者：
Valero-Muñoz M;Backman W;Sam F
射血分数保留的心力衰竭（HFpEF）的特征是左心室射血分数正常的情况下出现心力衰竭的体征和症状。尽管 HFpEF 占所有心力衰竭临床表现的 50%，但人们对 HFpEF 所涉及的机制知之甚少，因此阻碍了有效的治疗。 HFpEF 表型的病理生理学异质性也导致了这种疾病，并可能导致缺乏循证治疗。人类样本的获取有限，以及完全重现人类 HFpEF 表型的不完善的动物模型，阻碍了我们对这种疾病存在的机制基础的理解。 衰老和心房颤动、高血压、糖尿病和肥胖、肺动脉高压和肾功能不全等合并症与 HFpEF 高度相关，但它们之间的关系和贡献仍然不明确。本综述讨论了与这些合并症相关的 HFpEF 的一些独特临床特征，并强调了用于研究 HFpEF 表型的常用小鼠模型的优点和缺点。
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and symptoms of heart failure in the presence of a normal left ventricular ejection fraction. Despite accounting for up to 50% of all clinical presentations of heart failure, the mechanisms implicated in HFpEF are poorly understood, thus precluding effective therapy. The pathophysiological heterogeneity in the HFpEF phenotype also contributes to this disease and likely to the absence of evidence-based therapies. Limited access to human samples and imperfect animal models that completely recapitulate the human HFpEF phenotype have impeded our understanding of the mechanistic underpinnings that exist in this disease. Aging and comorbidities such as atrial fibrillation, hypertension, diabetes and obesity, pulmonary hypertension, and renal dysfunction are highly associated with HFpEF, yet the relationship and contribution between them remains ill-defined. This review discusses some of the distinctive clinical features of HFpEF in association with these comorbidities and highlights the advantages and disadvantage of commonly used murine models used to study the HFpEF phenotype.