Protective Effect of α-Lipoic Acid Against Arsenic Trioxide-Induced Acute Cardiac Toxicity in Rats
Protective Effect of α-Lipoic Acid Against Arsenic Trioxide-Induced Acute Cardiac Toxicity in Rats
复制标题
DOI：
10.1254/jphs.10280sc
复制
发表时间：
2011-02-01
影响因子：
3.5
通讯作者：
Fujimura, Akio
中科院分区：
文献类型：
--
作者：
Kumazaki, Masafumi;Ando, Hitoshi;Fujimura, Akio
三氧化二砷（ATO）的临床应用往往因其不良反应而受到限制。我们研究了α-硫辛酸（LA）是否可以防止ATO诱导的心脏毒性。在长期研究中，ATO重复给药后，4只大鼠中有2只突然死亡，而与LA联合给药时未观察到死亡。在急性研究中，连续心电图记录显示，静脉注射ATO引起一过性ST-T改变，而LA预处理可消除ATO引起的所有动物的心电图异常。这些结果表明，LA对ATO诱导的大鼠急性心脏毒性和随后的猝死具有保护作用。
The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether alpha-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in combination with LA. In the acute study, continuous ECG recording revealed that intravenous injection of ATO caused transient ST-T change, whereas pretreatment with LA abolished the ATO-induced ECG abnormality in all animals. These results suggest that LA protects against the ATO-induced acute cardiac toxicity and subsequent sudden death in rats.