Utilizing selenious acid to reverse selenium deficiency in total parenteral nutrition patients.
Utilizing selenious acid to reverse selenium deficiency in total parenteral nutrition patients.
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利用亚硒酸逆转全肠外营养患者的硒缺乏症。
DOI：
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发表时间：
1984
影响因子：
7.1
通讯作者：
L. Buchanan
中科院分区：
文献类型：
--
作者：
R. J. Baptista;B. Bistrian;G. Blackburn;D. Miller;C. Champagne;L. Buchanan
评估了亚硒酸对8例成人家庭TPN患者硒缺乏的逆转能力。最初，通过比较患者血浆硒水平（平均值= 0.035微克/克）与10名对照组（平均值= 0.117微克/克）（p小于0.001），以及比较患者（平均值= 8.93）与对照组（平均值= 31.76）红细胞谷胱甘肽过氧化物酶（GSHPx）活性（作为mumol NADPH氧化/g Hb/min） （p小于0.002），证实了硒缺乏。随后，患者在总肠外营养液中添加100微克/天的亚硒酸。补充硒后的血浆硒水平平均为0.101微克/克，红细胞GSHPx活性平均为17.56。与治疗前相比，患者血浆硒水平差异有统计学意义（p < 0.001）。此外，恢复后的水平与对照组之间没有显著差异。补充后红细胞GSHPx活性（平均值= 17.56）与初始患者值无显著差异，尽管活性增加了一倍。此外，添加后的酶活性与对照组存在显著差异（p < 0.03）。我们得出结论，亚硒酸能够使血浆中缺乏的GSHPx水平正常化，但不能使红细胞中缺乏的GSHPx活性正常化。
The ability of selenious acid to reverse selenium deficiency in eight adult home TPN patients was assessed. Initially, deficiency was documented by comparing both plasma selenium levels in patients (means = 0.035 micrograms/g) to those of 10 controls (means = 0.117 micrograms/g) (p less than 0.001) and by comparing erythrocyte glutathione peroxidase (GSHPx) activity, as mumol NADPH oxidized/g Hb/min, in patients (means = 8.93) to controls (means = 31.76) (p less than 0.002). Subsequently, patients added 100 micrograms/day of selenious acid to their total parenteral nutrition solutions. Postsupplementation selenium status demonstrated a mean plasma level of 0.101 micrograms/g and a mean erythrocyte GSHPx activity of 17.56. Statistically, patients' plasma selenium levels were significantly different (p less than 0.001) when compared to pretreatment levels. Additionally, there was no significant difference between the restored levels and the levels of the controls. Postsupplementation erythrocyte GSHPx activity (means = 17.56) was not significantly different from the initial patient values, although activity did double. Additionally, there existed a significant difference between the postsupplementation enzyme activity and the controls (p less than 0.03). We conclude that selenious acid is able to normalize deficient plasma levels but not deficient erythrocyte GSHPx activity.
DOI：
10.1056/nejm198105143042005
发表时间：
1981
期刊：
The New England journal of medicine
影响因子：
--
作者：
Johnson,RA;Baker,SS;Fallon,JT;Maynard3rd,EP;Ruskin,JN;Wen,Z;Ge,K;Cohen,HJ
通讯作者：
Cohen,HJ