The courtship of proteins: Understanding the encounter complex
The courtship of proteins: Understanding the encounter complex
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DOI：
10.1016/j.febslet.2009.02.046
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发表时间：
2009-04
期刊：
影响因子：
3.5
通讯作者：
M. Ubbink
中科院分区：
文献类型：
--
作者：
M. Ubbink
蛋白质复合体的形成涉及到一个相遇复合体，在这个复合体中，蛋白质表现出很少的特定相互作用，并呈现多种方向。最近的动力学和结构研究揭示了这种难以捉摸的状态。它通常是由静电相互作用主导的，尽管疏水相互作用也可以发挥作用。在相遇阶段，蛋白质在很大程度上保持溶解状态。在极端情况下，蛋白质只形成相遇复合体，而在许多其他复合体中，相遇状态构成了相当大的量(5%或更多)，这表明相遇和生产性复合体之间的能量差异很小。因此，相遇复合体是蛋白质复合体的重要组成部分。
The formation of protein complexes involves an encounter complex, in which proteins show few specific interactions and assume many orientations. Recent kinetic and structural studies have shed light on this elusive state. It is generally dominated by electrostatic interactions, although hydrophobic interactions can play a role. During the encounter phase the proteins remain largely solvated. In extreme cases, the proteins only form an encounter complex, and in many other complexes, the encounter state constitutes a significant amount (5% or more), indicating that the energy difference between encounter and productive complexes is small. Thus, the encounter complex represents an essential part of protein complexes.