Building a bio-based hydrogel via electrostatic and host-guest interactions for realizing dual-controlled release mechanism.
Building a bio-based hydrogel via electrostatic and host-guest interactions for realizing dual-controlled release mechanism.
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DOI：
10.1016/j.ijbiomac.2017.07.049
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发表时间：
2017-12
影响因子：
8.2
通讯作者：
Shuai Han;Ting Wang;Li Yang-;Bin Li
中科院分区：
文献类型：
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作者：
Shuai Han;Ting Wang;Li Yang-;Bin Li
环糊精（CD）生物基水凝胶是一种很有前途的高分子材料，具有广泛的可利用性、可持续性、生物相容性和生物降解性，特别是与疏水性物质的固有包封能力。通过引入静电相互作用和主客体相互作用，构建了具有三维双网结构的水凝胶。为了制备球形生物聚合物笼，羟乙基纤维素（HEC）和改性壳聚糖（HACC）通过一锅反应交联。HACC在该水凝胶中的存在提供了一个带正电荷的核心，以吸引带负电荷的主体分子磺丁基醚-β-环糊精（SEB-β-CD）。分别采用增重法和光度滴定法测定了SEB-β-CD的负载量，结果表明，所制备的水凝胶中SEB-β-CD的平均负载量大于50%，远高于CD在生物高分子材料上的化学接枝。通过主客体间的相互作用，聚丙烯疏水分子可以在水凝胶中快速吸附，并在水溶液中持续释放。通过离子交换作用，研究不同阴离子对SEB-β-CD的控制释放，达到快速释放疏水客体分子的目的。
Bio-based hydrogel containing cyclodextrins (CDs) is of a promising polymer material that could display many advantages including wide availability, sustainability, biocompatibility and biodegradability, especially the inherent encapsulation ability with hydrophobic substance. To obtain these, the electrostatic and host-guest interactions were introduced and a hydrogel with three-dimensional double network structures was built. For preparing a spherical biopolymer cage, hydroxyethyl cellulose (HEC) and modified chitosan (HACC) were cross-linked by a one-pot reaction. The existence of HACC in this hydrogel provides a positive charge core to attract negative host molecule of sulfobutylether-β-cyclodextrin (SEB-β-CD). The loading amount of SEB-β-CD were determined by the method of weight increment and photometric titration, respectively, and an average content of active SEB-β-CD in our prepared hydrogel is more than 50%, much higher than the grafting of CD on biopolymers materials through chemical reaction. By the host-guest interaction, hydrophobic molecule of PP could adsorb rapidly in our prepared hydrogel and sustain-release in aqueous solution. Through ion-exchange interaction, different negative ions were studied for obtaining a control release of SEB-β-CD, which is to achieve the purpose of rapid release of hydrophobic guest molecule.