Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission
Schizoaffective illness, schizophrenia and affective disorders: morbidity risk and genetic transmission
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分裂情感性疾病、精神分裂症和情感障碍：发病风险和遗传传播
DOI：
10.1111/j.1600-0447.1982.tb00845.x
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发表时间：
1982
影响因子：
6.7
通讯作者：
John M. Kane
中科院分区：
文献类型：
--
作者：
Miron Baron;R. Gruen;L. Asnis;John M. Kane
收集了情感性疾病、精神分裂症和情感性精神障碍的数据，这些数据来自情感性先证者的一级亲属和匹配的对照组（双极、单极和精神分裂症患者）。情感性精神障碍的情感和精神分裂症亚型的家族模式分别类似于情感和精神分裂症先证者的家族模式。与情感性抑郁先证者的亲属相比，情感性躁狂和情感性精神障碍的总体风险在情感性躁狂的亲属中更高，尽管差异不显著。当测试与遗传传递的多阈值假设的一致性时，情感性疾病既不符合情感性疾病的更极端形式，也不符合占据双相和单相障碍之间的中间位置或遗传上比情感性障碍温和的障碍。本文还讨论了诊断亚型对重大精神病遗传学研究的意义。
Data on schizoaffective illness, schizophrenia and affective disorders were gathered on first‐degree relatives of schizoaffective probands and matched controls (bipolars, unipolars and schizophrenics). The familial pattern of affective and schizophrenic subtypes of schizoaffective disorder resembled the familial pattern of affective and schizophrenic probands, respectively. The overall risk for the spectrum of schizoaffective and affective disorders was higher among relatives of schizoaffective‐manic as compared to relatives of schizoaffective‐depressive probands, although the difference fell short of significance. When tested for consistency with multiple threshold hypotheses of genetic transmission, schizoaffective illness did not qualify as either a more extreme form of affective illness nor as a disorder that occupies an intermediate position between bipolar and unipolar disorders or is genetically milder than affective disorder. The implications of diagnostic subtyping for genetic research in the major psychoses were discussed.