RESPIRATORY EFFECTS OF BRIEF BARORECEPTOR STIMULI IN THE ANESTHETIZED DOG
RESPIRATORY EFFECTS OF BRIEF BARORECEPTOR STIMULI IN THE ANESTHETIZED DOG
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DOI：
10.1152/jappl.1985.59.4.1258
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
KATONA, PG
中科院分区：
文献类型：
--
作者：
DOVE, EL;KATONA, PG
为了量化压力感受器刺激的即刻等颅压呼吸反应，在24只迷走神经切断的α-氯醛糖麻醉犬的离体外灌流颈动脉窦(CS)中选择性地增加吸气或呼气时的压力(从开始到呼吸期结束的时间)或脉冲(500ms)。两种刺激的上升时间(150ms)、基线压力(80 Mm Hg)和刺激幅度(40 Mm Hg)相似。刺激开始(延迟)时间(以对照吸气时间(TI)或呼气时间(TE)的百分比表示)是不同的。TI、TE和潮气量(VT)以与对照相比的百分比变化表示。在灵感早期给予的刺激延长了TI[23.5.+-.STEP为6.4%(SE)，11.7+-。6.3%用于延迟5%的脉冲刺激]比延迟刺激更有效。VT基本上是不变的。相反，在呼气时给予阶跃刺激导致TE延长(32.7±-)。6.3%，延迟为5%)，这与延迟无关(最高75%)。很晚(85%)的脉冲刺激使TE延长(15.2±-)。5.7%)比早期刺激更有效。对于这两种刺激，呼气VT没有改变。当比较颈动脉体血供与CS区分离前后的反应，以及神经节阻滞抑制反射性全身性降压前后的反应时，所观察到的反应仅是由于CS压力感受器的刺激，而不是颈动脉体血流量的改变或全身心血管变量的反射性变化。
To quantify the immediate isocapnic respiratory response to baroreceptor stimulation, pressure in the isolated externally perfused carotid sinuses (CS) of 24 vagotomized .alpha.-chloralose-anesthetized dogs was increased selectively during either inspiration or expiration as a step (from time of onset to end of respiratory phase) or a pulse (500 ms). The rise time (150 ms), base-line pressure (80 mm Hg), and stimulus magnitude (40 mm Hg) were similar for the two stimuli. The time of stimulus onset (delay), expressed as a percent of control time of inspiration (TI) or expiration (TE), was varied. TI, TE, and tidal volume (VT) were expressed as percent changes from control. Stimuli delivered early in inspiration lengthened TI [23.5 .+-. 6.4% (SE) for step and 11.7 .+-. 6.3% for pulse stimuli at 5% delay] more effectively than late stimuli. VT was essentially unaltered. In contrast, step stimuli delivered during expiration caused a lengthening of TE (32.7 .+-. 6.3% at 5% delay) that did not depend on the delay (up to 75%). Very late (85%) pulse stimuli lengthened TE (15.2 .+-. 5.7%) more effectively than early stimuli. For both stimuli, the expiratory VT was unaltered. When the responses are compared before and after separation of the blood supply of the carotid bodies from the CS region and when they are compared before and after inhibition of reflex systemic hypotension by ganglionic blockade, the observed responses were shown to be due solely to CS baroreceptor stimulation and not to alterations in carotid body blood flow or reflex changes in systemic cardiovascular variables.