Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
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DOI：
10.1038/s41591-020-0817-4
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发表时间：
2020-03-13
期刊：
影响因子：
82.9
通讯作者：
Gong, Sitang
中科院分区：
文献类型：
--
作者：
Xu, Yi;Li, Xufang;Gong, Sitang
我们报告了10例儿童SARS冠状病毒2型感染病例的流行病学和临床调查，这些病例经SARS冠状病毒2型RNA的实时逆转录PCR检测证实。这些病例的症状是非特异性的，没有儿童需要呼吸支持或重症监护。胸部X光检查缺乏明确的肺炎体征，这是成人感染的一个典型特征。值得注意的是，8名儿童在鼻咽检测呈阴性后，直肠拭子检测持续呈阳性，这增加了粪-口传播的可能性。感染COVID-19爆发的冠状病毒SARS-CoV-2的儿童表现出轻微症状，但粪便中的病毒RNA脱落时间较长，这表明粪-口途径可能在病毒传播中发挥作用。
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.Children infected with the COVID-19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal-oral route might play a role in virus transmission.