Associations between total serum GGT activity and metabolic risk: MESA.
Associations between total serum GGT activity and metabolic risk: MESA.
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DOI：
10.2217/bmm.13.71
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发表时间：
2013-10
影响因子：
2.2
通讯作者：
Jacobs DR Jr
中科院分区：
文献类型：
--
作者：
Bradley R;Fitzpatrick AL;Jenny NS;Lee DH;Jacobs DR Jr
评估梅萨患者血清总GGT活性、代谢危险因素与代谢性疾病患病率之间的关系。在整个梅萨队列和代谢性疾病亚组中，使用线性回归模型对GGT与空腹血糖（FBG）、空腹胰岛素、HbA 1c和胰岛素抵抗稳态模型评估指数（HOMA-IR）之间的持续相关性进行了评估，该模型根据年龄、性别、部位、种族、生活方式、传统危险因素和药物进行了增量调整。在整个队列和按年龄（≥65岁）和种族定义的亚组中，计算GGT五分位数的普遍FBG受损、代谢综合征和2型糖尿病的横截面几率。在多变量模型中，GGT活性与FBG、空腹胰岛素、HbA 1c和HOMA-IR之间存在显著相关性，GGT与BMI之间的相互作用影响GGT与HOMA-IR之间的相关性以及BMI与HOMA-IR之间的相关性（p < 0.0001）。在整个队列中，五分位数为5与1的人群中，普遍存在的FBG受损、代谢综合征和2型糖尿病的校正比值比（95%CI）分别为2.4（1.7-3.5）、3.3（2.5-4.5）和2.8（1.8-4.4）（p < 0.0001）。GGT相关性随年龄增长而减弱。通过增加GGT五分位数而增加的流行代谢疾病的线性趋势的显著性因种族而异。在梅萨队列中，GGT与心血管和代谢危险因素（包括流行性代谢疾病）密切相关。
To evaluate associations between total serum GGT activity, metabolic risk factors and prevalent metabolic disease in MESA. Continuous associations between GGT and fasting blood glucose (FBG), fasting insulin, HbA1c and Homeostasis Model Assessment Index of Insulin Resistance (HOMA–IR) were evaluated in the entire MESA cohort and in metabolic disease subgroups using linear regression models incrementally adjusted for age, gender, site, race, lifestyle, traditional risk factors and medications. Cross-sectional odds of prevalent impaired FBG, metabolic syndrome and Type 2 diabetes were calculated for GGT quintiles in the entire cohort and in subgroups defined by age (< or ≥65 years) and ethnicity. In multivariable models, significant associations were present between GGT activity and FBG, fasting insulin, HbA1c and HOMA–IR, with the interaction between GGT and BMI affecting the association between GGT and HOMA–IR as well as the association between BMI and HOMA–IR (p < 0.0001). Adjusted odds ratios (95% CIs) of prevalent impaired FBG, metabolic syndrome and Type 2 diabetes for quintile 5 versus 1 in the entire cohort were 2.4 (1.7–3.5), 3.3 (2.5–4.5) and 2.8 (1.8–4.4), respectively (p < 0.0001). GGT associations weakened with age. The significance of linear trends for increased prevalent metabolic disease by increasing GGT quintile varied by ethnicity. GGT is strongly associated with both cardiovascular and metabolic risk factors, including prevalent metabolic disease, in the MESA cohort.