Heterochromatin protein 1 (HP1): interactions with itself and chromatin components.
Heterochromatin protein 1 (HP1): interactions with itself and chromatin components.
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DOI：
10.1007/s12551-020-00663-y
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发表时间：
2020-04-01
影响因子：
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通讯作者：
Kono, Hidetoshi
中科院分区：
文献类型：
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作者：
Kumar, Amarjeet;Kono, Hidetoshi
异染色质蛋白1（HP1）的异构体已被称为执行从基因沉默，基因激活到细胞周期调控和细胞分化的多种功能。这种功能多样性源于蛋白质序列中编码的不同之处，其赋予HP 1的各个结构元件不同的生物物理和生物化学性质，从而赋予不同的行为和相互作用模式。因此，了解HP1结构元件的各种相互作用对于更好地阐明其存在下的染色质动力学至关重要。在这篇综述中，我们已经收集了有关HP1内部和与自身以及与染色质元素的相互作用的可用信息。此外，这些相互作用的可能影响进行了讨论。
Isoforms of heterochromatin protein 1 (HP1) have been known to perform a multitude of functions ranging from gene silencing, gene activation to cell cycle regulation, and cell differentiation. This functional diversity arises from the dissimilarities coded in protein sequence which confers different biophysical and biochemical properties to individual structural elements of HP1 and thereby different behavior and interaction patterns. Hence, an understanding of various interactions of the structural elements of HP1 will be of utmost importance to better elucidate chromatin dynamics in its presence. In this review, we have gathered available information about interactions of HP1 both within and with itself as well as with chromatin elements. Also, the possible implications of these interactions are discussed.