Simulations of Glomerular Shear and Hoop Stresses in Diabetes, Hypertension, and Reduced Renal Mass using a Network Model of a Rat Glomerulus.
Simulations of Glomerular Shear and Hoop Stresses in Diabetes, Hypertension, and Reduced Renal Mass using a Network Model of a Rat Glomerulus.
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DOI：
10.14814/phy2.14577
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发表时间：
2020-09
影响因子：
2.5
通讯作者：
Navar LG
中科院分区：
文献类型：
--
作者：
Richfield O;Cortez R;Navar LG
一种新的大鼠肾小球滤过的解剖学上精确的模型被用来量化肾小球毛细血管内皮细胞上的剪切应力和肾小球毛细血管壁上的环应力。血浆，红细胞体积和血浆蛋白质质量分布在网络节点使用的压力差计算考虑到过滤体积损失，改善以前的模型，只考虑血液表观粘度计算整个网络的压力。过滤被发现是不均匀地分布在整个肾小球毛细血管网络，并确定血浆蛋白的浓度和过滤毛细血管段的表面积。环向应力主要集中在传入小动脉附近，而剪切应力集中在传出小动脉附近。使用来自肾小球微穿刺研究的参数，模拟糖尿病（DM）、5/6-肾切除术（5/6-Nx）和血管紧张素II诱导的高血压（HTN）的条件，并与其自身的内部对照进行比较，以评估机械应力的变化。环向应力在所有三种情况下均增加，而剪切应力在5/6-Nx中增加，在HTN中降低，并通过肾小球毛细血管的肥大反应在DM中维持在对照水平。结果表明，机械应力的这些变化以及随之而来的肾小球细胞释放细胞因子或损伤可能在这些疾病的肾小球病进展中发挥重要作用。我们使用一种新的数学模型的血流和过滤在一个解剖学上准确的肾小球微血管网络，量化机械应力和过滤动力学为每个肾小球毛细血管。使用以前文献中的血流动力学数据，我们模拟高血压，糖尿病和肾功能衰竭的条件下，证明机械应力的变化，由于在这些疾病状态下的压力和流量的变化。我们的研究结果表明，机械应力可能在这些疾病条件下肾小球损伤的原因和/或进展中起着至关重要的作用。
A novel anatomically accurate model of rat glomerular filtration is used to quantify shear stresses on the glomerular capillary endothelium and hoop stresses on the glomerular capillary walls. Plasma, erythrocyte volume, and plasma protein mass are distributed at network nodes using pressure differentials calculated taking into account volume loss to filtration, improving on previous models which only took into account blood apparent viscosity in calculating pressures throughout the network. Filtration is found to be heterogeneously distributed throughout the glomerular capillary network and is determined by concentration of plasma proteins and surface area of the filtering capillary segments. Hoop stress is primarily concentrated near the afferent arteriole, whereas shear stress is concentrated near the efferent arteriole. Using parameters from glomerular micropuncture studies, conditions of diabetes mellitus (DM), 5/6‐Nephrectomy (5/6‐Nx), and Angiotensin II‐induced hypertension (HTN) are simulated and compared to their own internal controls to assess the changes in mechanical stresses. Hoop stress is increased in all three conditions, while shear stress is increased in 5/6‐Nx, decreased in HTN, and maintained at control levels in DM by the hypertrophic response of the glomerular capillaries. The results indicate that these alterations in mechanical stresses and the consequent release of cytokines by or injury of the glomerular cells may play a significant role in the progression of glomerulopathy in these disease conditions. We use a novel mathematical model of blood flow and filtration in an anatomically accurate glomerular microvascular network to quantify mechanical stresses and filtration dynamics for each glomerular capillary. Using hemodynamic data from previous literature, we simulate hypertensive, diabetic and renoprival conditions to demonstrate that mechanical stresses are changed due to alterations in pressure and flow in these disease states. Our results indicate that mechanical stress may play a crucial role in the cause and/or progression of glomerular injury in these disease conditions.
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DOI：
10.1111/j.1365-2818.1993.tb03356.x
发表时间：
1993-07-01
期刊：
JOURNAL OF MICROSCOPY-OXFORD
影响因子：
--
作者：
NYENGAARD, JR;MARCUSSEN, N
通讯作者：
MARCUSSEN, N
影响因子：
20.1
作者：
PRIES, AR;SECOMB, TW;GAEHTGENS, P
通讯作者：
GAEHTGENS, P
DOI：
10.1161/01.atv.0000106321.63667.24
发表时间：
2004-01-01
影响因子：
8.7
作者：
Chiu, JJ;Lee, PL;Chien, S
通讯作者：
Chien, S
影响因子：
3.1
作者：
LIPOWSKY, HH;USAMI, S;CHIEN, S
通讯作者：
CHIEN, S
影响因子：
15.9
作者：
OHNO, M;COOKE, JP;GIBBONS, GH
通讯作者：
GIBBONS, GH