Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma.
Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma.
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DOI：
10.1016/j.anl.2016.04.004
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
R. Yasumatsu;T. Nakashima;Masanobu Sato;T. Nakano;Ryunosuke Kogo;K. Hashimoto;M. Sawatsubashi;T. Nakagawa
中科院分区：
文献类型：
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作者：
R. Yasumatsu;T. Nakashima;Masanobu Sato;T. Nakano;Ryunosuke Kogo;K. Hashimoto;M. Sawatsubashi;T. Nakagawa
目的探讨鼻腔鼻窦内翻性乳头状瘤（IP）合并鳞状细胞癌（SCC）的临床特点及预后。95名患者中，15名被诊断出患有与IP相关的SCC。分析了患者的临床特征、治疗方式和生存结局。结果与IP相关的SCC发生率为15.8%。虽然IP和SCC伴IP的鉴别诊断是困难的，鼻出血可能是SCC伴IP病例的特异性症状。T1、T2和T3的3年疾病特异性生存率高于T4。上颌窦与其他原发部位之间的生存率差异无统计学意义。另一方面，显微镜下SCC伴IP病例与其他病例之间的生存率有显著差异。70岁以上患者<70 years old better than those with >3年无瘤生存率为80%对0。结论部分T4患者存在高度侵袭性疾病。因此，完整的手术切除术后进行化学放射治疗是T4疾病患者控制原发肿瘤部位的推荐治疗方法。
ObjectiveThe aim of this study was to investigate the clinical features and prognosis of patients with squamous cell carcinoma (SCC) associated with sinonasal inverted papilloma (IP).MethodsThe medical records of 95 patients who were diagnosed with IP or SCC associated with IP were retrospectively reviewed. Out of 95 patients, 15 were diagnosed with SCC associated with IP. The clinical characteristics, treatment modalities, and survival outcomes of the patients were analyzed.ResultsThe incidence of SCC associated with IP was 15.8%. Although differential diagnosis between IP and SCC associated with IP is difficult, epistaxis may be the specific symptom in SCC associated with IP cases. The 3-year disease-specific survival rate was higher in cases with T1, 2 and 3 than in cases with T4. There was no significant difference in survival rate between maxillary sinus and other primary sites. On the other hand, there was a significant difference in survival rate between the microscopic SCC with IP cases and the other cases. In addition, the patients with <70 years old better than those with >70 years old with a 3-year disease free survival of 80% versus 0%.ConclusionsSome T4 patients were found to have a highly aggressive disease. Therefore, complete surgical resection followed by chemo-radiation therapy is the recommended treatment for patients with T4 disease to control of the primary tumor site.