AGE-DEPENDENT MECHANICAL-PROPERTIES OF RAT FEMUR - MEASURED INVIVO AND INVITRO
AGE-DEPENDENT MECHANICAL-PROPERTIES OF RAT FEMUR - MEASURED INVIVO AND INVITRO
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DOI：
10.3109/17453679108993602
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发表时间：
1991-06-01
期刊：
影响因子：
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通讯作者：
LANGELAND, N
中科院分区：
文献类型：
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作者：
INDREKVAM, K;HUSBY, OS;LANGELAND, N
将应变片植入6、12或52周龄大鼠股骨干前表面。 当大鼠在跑步机上跑步时记录应变。 不同动物年龄的峰值应变幅度相同，但52周龄动物的峰值应变略低。 从体内应变测量和从3点弯曲测试切除股骨计算的刚度相关：刚度随年龄增加。 最大弯曲应力从6-12周龄开始增加，但随后没有进一步增加。 相反，极限载荷在整个52周期间稳步增加。 这表明成年大鼠随着年龄的增加而具有更高的承载能力是由于骨骼尺寸的增加而不是其材料特性。 本研究表明，传统的体外测量骨的机械性能对应于测量的应变在体力活动，这两个是有效的测量骨的物理特性。
Strain gauges were implanted on the anterior surface of the femoral diaphysis of rats aged 6, 12 or 52 weeks. Strain was recorded while the rats were running on a treadmill. The peak strain was of the same magnitude at different animal ages, although there was a somewhat lower value for 52-week-old animals. Stiffness calculated from in vivo strain measurements and from a 3-point bending test on excised femora was correlated: stiffness increased with age. Maximum bending stress increased from 6-12 weeks of age, but then there was no further increase. Ultimate load, on the contrary, increased steadily over the entire 52-week period. This indicates that higher load-bearing capacity with increased age in adult rats is due to increased dimensions of the bone rather than its material properties. The present study demonstrates that conventional in vitro measurements of mechanical properties of bone correspond to measurements of strain during physical activity, and that both are valid measurements of physical properties of bone.