NEUROEXCITATORY PLASMA AMINO-ACIDS ARE ELEVATED IN MIGRAINE
NEUROEXCITATORY PLASMA AMINO-ACIDS ARE ELEVATED IN MIGRAINE
复制标题
DOI：
10.1212/wnl.40.10.1582
复制
发表时间：
1990-10-01
期刊：
影响因子：
9.9
通讯作者：
BRUYN, GW
中科院分区：
文献类型：
--
作者：
FERRARI, MD;ODINK, J;BRUYN, GW
为探讨谷氨酸（Glu）和天冬氨酸（Asp）在偏头痛中的作用，测定了有先兆和无先兆偏头痛患者、发作期和发作间的血浆氨基酸水平，并与紧张性头痛患者和健康对照者的血浆氨基酸水平进行比较。在发作之间，偏头痛患者（特别是有先兆的）的血浆Glu和Asp水平明显高于对照组和紧张性头痛患者。此外，无先兆偏头痛患者血浆组氨酸水平较低。在偏头痛发作期间，Glu（以及较小程度的Asp）水平甚至进一步增加。结果表明，有缺陷的细胞再摄取机制，谷氨酸和天冬氨酸偏头痛，我们假设在神经元/神经胶质细胞水平的类似缺陷，诱发偏头痛的大脑发展扩散性抑郁症。
To investigate the role of glutamic (Glu) and aspartic acid (Asp) in migraine, we measured the plasma amino acids in migraine patients with and without aura, between and during attacks, and compared the profiles with the plasma amino acid profiles of tension headache patients and healthy controls. Between attacks, migraineurs (notably with aura) had substantially higher plasma Glu and Asp levels than did controls and tension headache patients. In addition, patients with migraine without aura showed low plasma histidine levels. During migraine attacks, Glu (and to a lesser extent Asp) levels were even further increased. The results suggest a defective cellular reuptake mechanism for Glu and Asp in migraineurs, and we hypothesize a similar defect at the neuronal/glial cell level, predisposing the brain of migraineurs to develop spreading depression.