Protein folding and secretion: mechanistic insights advancing recombinant protein production in S. cerevisiae.
Protein folding and secretion: mechanistic insights advancing recombinant protein production in S. cerevisiae.
复制标题
DOI：
10.1016/j.copbio.2014.06.018
复制
发表时间：
2014-12
影响因子：
7.7
通讯作者：
Robinson, Anne S.
中科院分区：
文献类型：
--
作者：
Young, Carissa L.;Robinson, Anne S.
The emergence of genomic approaches coupled to recombinant DNA technologies have identified the quality control systems that regulate proteostasis — biological pathways that modulate protein biogenesis, maturation, trafficking, and degradation. The elucidation of these pathways has become of growing importance in therapeutics as loss of proteostasis has been suggested to lead to a number of human diseases including Alzheimer’s, Parkinson’s Disease and Type II Diabetes. We anticipate that the most successful strategies for protein expression and therapeutics development may involve integration of protein engineering strategies with host manipulation, to exploit the cell’s native stress response pathways and trafficking mechanisms. This review will highlight recent findings and mechanistic detail correlated to quality control in the early secretory pathway of S. cerevisiae.
登录
查看更多内容
影响因子：
5
作者：
Butler M;Meneses-Acosta A
通讯作者：
Meneses-Acosta A
影响因子：
16
作者：
Bhamidipati, A;Denic, V;Weissman, JS
通讯作者：
Weissman, JS
DOI：
10.1073/pnas.0710412105
发表时间：
2008-03-04
影响因子：
11.1
作者：
Amano, Koh;Chiba, Yasunori;Narimatsu, Hisashi
通讯作者：
Narimatsu, Hisashi
DOI：
10.1083/jcb.135.1.19
发表时间：
1996-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bannykh SI;Rowe T;Balch WE
通讯作者：
Balch WE
影响因子：
4.8
作者：
Chiba, Y;Suzuki, M;Ichishima, K
通讯作者：
Ichishima, K