Multivalent Glycosheets for Double Light Driven Therapy of Multidrug-Resistant Bacteria on Wounds
Multivalent Glycosheets for Double Light Driven Therapy of Multidrug-Resistant Bacteria on Wounds
复制标题
用于伤口上多重耐药细菌双重光驱动治疗的多价糖片
DOI：
10.1002/adfm.201806986
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发表时间：
2019-04-04
影响因子：
19
通讯作者：
Tian, He
中科院分区：
文献类型：
--
作者：
Hu, Xi-Le;Chu, Linyang;Tian, He
随着细菌多药耐药性的威胁日益严重，开发有效的抗菌药物仍然是一个全球性的挑战。医院内多重耐药细菌的感染会严重损害深度烧伤或糖尿病足溃疡引起的伤口愈合，导致这些患者的高死亡率。本文开发了一种用于双光驱动治疗伤口上多重耐药铜绿假单胞菌（P. aeruginosa）感染的多价糖页。基于半乳糖和岩藻糖的配体自组装以在薄层二硫化钼表面上形成糖层，产生能够通过多价碳水化合物-凝集素相互作用选择性定位铜绿假单胞菌的糖片。负载有抗生素的糖片已被证明适用于：1）近红外光驱动的抗生素原位热释放，增加细菌膜渗透性，和2）白色光驱动的活性氧物质产生，以更彻底地杀死细菌。糖片的靶向性以及光敏感性使得能够实现高度有效和光学控制的治疗方案，用于治愈由多重耐药以及临床分离的铜绿假单胞菌感染的伤口。
With the evergrowing threat posed by multidrug resistance of bacteria, the development of effective antibacterial agents remains a global challenge. Infection with multidrug-resistant bacteria in hospitals significantly impairs the healing of wounds caused by deep-burn injuries or diabetic foot ulceration, leading to a high mortality rate among these patients. A multivalent glycosheet for the double light-driven therapy against multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infection on wounds is developed here. Galactose- and fucose-based ligands are self-assembled to form a glyco-layer on the surface of thin-layer molybdenum disulfide, producing the glycosheets capable of selectively localizing P. aeruginosa through multivalent carbohydrate-lectin interactions. The glycosheets loaded with antibiotics have proven applicable for: 1) near-infrared-light driven, in situ thermal release of antibiotics, increasing bacterial membrane permeability, and 2) white light-driven reactive-oxygen-species production to more thoroughly kill the bacteria. The targetability, together with the light sensibility, of the glycosheets enables a highly effective and optically controlled therapeutic regime for the healing of wounds infected by multidrug-resistant as well as clinically isolated P. aeruginosa.