Overestimation of the risk of progression to end-stage renal disease in the poor prognosis’ group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy
Overestimation of the risk of progression to end-stage renal disease in the poor prognosis’ group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy
复制标题
根据 2002 年日本免疫球蛋白 A 肾病组织学分类，高估了不良预后组进展为终末期肾病的风险
DOI：
10.1007/s10157-013-0848-y
复制
发表时间：
2013
影响因子：
2.3
通讯作者：
Y. Tomino
中科院分区：
文献类型：
--
作者：
Y. Miyazaki;T. Kawamura;K. Joh;H. Okonogi;K. Koike;Y. Utsunomiya;M. Ogura;M. Matsushima;M. Yoshimura;S. Horikoshi;Yusuke Suzuki;A. Furusu;T. Yasuda;Sayuri Shirai;T. Shibata;M. Endoh;M. Hattori;Y. Akioka;R. Katafuti;A. Hashiguchi;K. Kimura;S. Matsuo;Y. Tomino
背景免疫球蛋白A肾病的当前（2012年）组织学分类是通过对287例患者的病例对照研究建立的。然而，进展为终末期肾病（ESRD）的风险尚未在先前（2002）分类中得到验证。本研究旨在通过对2012年队列的重新分析，确定以前的分类是否可以识别长期肾脏结局的风险。方法在2002年分类的基础上，即“良好的肾功能”，“相对良好的肾功能”，“相对较差的肾功能”和“较差的肾功能”，我们检查了活检时的临床资料，2002年分类与长期肾脏结局之间的相关性，以及2002年和2012年分类系统之间的患者相关性。这是通过分析样本的287例患者用于建立2012 classification.ResultsThe估计肾小球滤过率的下降率更大，进展为终末期肾病的优势比是较高的“预后不良”组。相比之下，肾死亡的比值比在2002年分类中被描述为“相对预后差”和“相对预后好”的组之间具有可比性。许多患者在2002年的分类与较低的组织学分级在目前的classification，但没有被归类为一个较高的grade.ConclusionsThe 2002年的分类也可以确定进展为ESRD的风险。然而，在2002年分类中，对“预后不良”组的患者估计过高，因为该组包括组织学损伤较轻的患者。
BackgroundThe current (2012) histological classification of immunoglobulin A nephropathy was established using a case–control study of 287 patients. However, the risk of progression to end-stage renal disease (ESRD) has not been validated for the previous (2002) classification. This study aimed to determine whether the previous classification could identify the risk of long-term renal outcome through re-analysis of the 2012 cohort.MethodsOn the basis of the 2002 classification, namely ‘good prognosis’, ‘relatively good prognosis’, ‘relatively poor prognosis’, and ‘poor prognosis’, we examined the clinical data at the time of biopsy, the correlation between the 2002 classification and long-term renal outcomes, and a patient-by-patient correlation between the 2002 and 2012 classification systems. This was performed by analyzing samples from the 287 patients used to establish the 2012 classification.ResultsThe rate of decline of estimated glomerular filtration rate was greater and the odds ratio of progression to ESRD was higher in the ‘poor prognosis’ group. In contrast, the odds ratio for renal death was comparable between the groups described as ‘relatively poor prognosis’ and ‘relatively good prognosis’ in the 2002 classification. Many patients in the 2002 classification were classified with a lower histological grade in the current classification, but none were classified with a higher grade.ConclusionsThe 2002 classification could also identify the risk of progression to ESRD. However, it was overestimated for patients in the ‘poor prognosis’ group in the 2002 classification, as that group included patients with milder histological damage.
影响因子：
2.3
作者：
Miura, Naoto;Imai, Hirokazu;Watanabe, Tsuyoshi
通讯作者：
Watanabe, Tsuyoshi