Memory T cell populations in the lung airways are maintained by continual recruitment
Memory T cell populations in the lung airways are maintained by continual recruitment
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DOI：
10.4049/jimmunol.176.1.537
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发表时间：
2006-01-01
影响因子：
4.4
通讯作者：
Woodland, DL
中科院分区：
文献类型：
--
作者：
Ely, KH;Cookenham, T;Woodland, DL
外周效应记忆T细胞群在继发感染的细胞免疫反应中起着关键作用。然而，目前尚不清楚这些群体是如何在非淋巴样外周部位(如肺部呼吸道)的稳定状态下维持的。在这项研究中，我们发现记忆T细胞进入肺气道后，LFA-1的表达被选择性地下调。使用仙台病毒作为呼吸道病毒感染的小鼠模型，我们使用LFA-1的表达水平来证明肺部呼吸道中的效应记忆T细胞群是通过不断从循环中招募新细胞来维持的。记忆细胞募集的速度惊人地快，导致每10天就有90%的人被替换，并在病毒清除后保持了一年多。这些数据表明，外周T细胞记忆是动态的，并依赖于T细胞的系统来源。
Effector memory T cell populations in the periphery play a key role in cellular immune responses to secondary infections. However, it is unclear how these populations are maintained under steady-state conditions in nonlymphoid peripheral sites, such as the lung airways. In this study, we show that LFA-1 expression is selectively down-regulated following entry of memory T cells into the lung airways. Using Sendai virus as a mouse model of respiratory virus infection, we use LFA-1 expression levels to demonstrate that effector memory T cell populations in the lung airways are maintained by continual recruitment of new cells from the circulation. The rate of memory cell recruitment is surprisingly rapid, resulting in replacement of 90% of the population every 10 days, and is maintained for well over 1 year following viral clearance. These data indicate that peripheral T cell memory is dynamic and depends on a systemic source of T cells.