Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway
Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway
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DOI：
10.1016/s0925-4773(02)00004-7
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发表时间：
2002-04-01
影响因子：
2.6
通讯作者：
Nishimune, Y
中科院分区：
文献类型：
--
作者：
Tadokoro, Y;Yomogida, K;Nishimune, Y
干细胞的调控机制很难研究，因为自我更新和分化后代的产生都受到严格控制，同时发生在这些细胞中。为了单独关注自我更新机制，我们研究了具有缺陷的GSC分化的子代缺陷睾丸中的GSC的行为。在这些睾丸中，我们发现，未分化的精原细胞，其中一些是GSC的增殖，被高浓度的胶质细胞源性神经营养因子（GDNF）加速。此外，我们发现，卵泡刺激素（FSH）刺激通过稳态控制GDNF浓度的主要调节因子之一。这些结果表明，在哺乳动物睾丸，GSC增殖和人口规模的调节稳态GDNF/FSH途径。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Stem cell regulatory mechanisms are difficult to study because self-renewal and production of differentiated progeny, which are both strictly controlled, occur simultaneously in these cells. To focus on the self-renewal mechanism alone, we investigated the behavior of germinal stem cells (GSCs) in progeny-deficient testes with defective GSC differentiation. In these testes, we found that the proliferation of undifferentiated spermatogonia, some of which are GSCs, was accelerated by high concentrations of glial cell line-derived neurotrophic factor (GDNF). Furthermore, we found that follicle-stimulating hormone (FSH) stimulation via homeostatic control was one of the major regulators of GDNF concentration. These results suggest that in mammalian testes, GSC proliferation and population size are regulated homeostatically by the GDNF/FSH pathway. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.