Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model
Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model
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DOI：
10.1115/1.4027468
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发表时间：
2014-07-01
影响因子：
1.7
通讯作者：
Donahue, Tammy L. Haut
中科院分区：
文献类型：
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作者：
Fischenich, Kristine M.;Coatney, Garrett A.;Donahue, Tammy L. Haut
创伤后骨关节炎(PTOA)是创伤性负荷导致膝关节软组织撕裂的结果。采用改良的横断前交叉韧带(ACL)和双侧半月板的方法，对成年佛兰德巨兔进行横断实验。测定损伤后12周的大体形态、弹性系数和半月板的糖胺多聚糖(GAG)覆盖率，以量化组织损伤量。这项研究是第一批监测半月板和前交叉韧带联合横断后半月板变化的研究之一。弹性模数下降，GAG覆盖率下降。
Post-traumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.