Multiple modes for gatekeeping at fungal cell-to-cell channels
Multiple modes for gatekeeping at fungal cell-to-cell channels
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DOI：
10.1111/mmi.12074
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发表时间：
2012-12-01
影响因子：
3.6
通讯作者：
Pieuchot, Laurent
中科院分区：
文献类型：
--
作者：
Jedd, Gregory;Pieuchot, Laurent
细胞间通道似乎对于成功的多细胞组织是不可或缺的，并且在动物、植物和真菌中独立出现。大多数真菌通过探索性和侵入性的方式生长从环境中获取营养，这种能力依赖于被称为菌丝的多细胞丝。这些细胞通过尖端延伸生长，并可以通过细胞壁分为隔室，细胞壁通常保留允许细胞间运输和合作的中央孔。在丝状子囊菌门的主要进化枝中，这种共生细胞组织的完整性是由沃罗宁体细胞器维持的，这些细胞器充当间隔孔的紧急斑块。在本期《分子微生物学》中，Bleichrodt 及其同事表明，Woronin 小体也可以与孔形成紧密的可逆关联，并进一步将其与区室基因表达水平的变化联系起来。这些数据定义了沃罗宁身体依赖的另一种守门模式。本评论重点关注这项工作的意义以及不同孔门控模式在控制真菌组织生长和发育中的潜在作用。
Cell-to-cell channels appear to be indispensable for successful multicellular organization and arose independently in animals, plants and fungi. Most of the fungi obtain nutrients from the environment by growing in an exploratory and invasive manner, and this ability depends on multicellular filaments known as hyphae. These cells grow by tip extension and can be divided into compartments by cell walls that typically retain a central pore that allows intercellular transport and cooperation. In the major clade of filamentous Ascomycota, integrity of this coenocytic organization is maintained by Woronin body organelles, which function as emergency patches of septal pores. In this issue of Molecular Microbiology, Bleichrodt and co-workers show that Woronin bodies can also form tight reversible associations with the pore and further link this to variation in levels of compartmental gene expression. These data define an additional modality of Woronin body-dependent gatekeeping. This commentary focuses on the implications of this work and the potential role of different modes of pore gating in controlling the growth and development of fungal tissues.