Free-Blockage Mesoporous Anticancer Nanoparticles Based on ROS-Responsive Wetting Behavior of Nanopores
Free-Blockage Mesoporous Anticancer Nanoparticles Based on ROS-Responsive Wetting Behavior of Nanopores
复制标题
基于纳米孔ROS响应润湿行为的自由阻塞介孔抗癌纳米粒子
DOI：
10.1002/smll.201701942
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发表时间：
2017-10-25
期刊：
影响因子：
13.3
通讯作者：
Zhang, Xueji
中科院分区：
文献类型：
--
作者：
Cheng, Yaya;Jiao, Xiangyu;Zhang, Xueji
为了达到良好的药物传递效果，通常在介孔二氧化硅纳米载体(MSN)表面构建具有物理封闭单元的刺激响应型纳米门。在自然界中，细胞膜上的水通道蛋白可以通过调节通道的润湿性来控制水分子的运输，这是由于通道中氨基酸的构象变化所致。受这一现象的启发，本文提出了一种新的自由堵塞控制释放系统的概念，通过控制纳米孔内表面在MSN上的润湿性来实现。这种新的系统不同于物理阻塞控释系统，它绕过了纳米门的使用，克服了传统物理阻塞系统的局限性。此外，进一步的研究表明，该系统可以选择性地释放由细胞内活性氧(ROS)触发的人乳腺腺癌细胞(MCF-7)中的阿霉素，但不能在含有低水平ROS的正常人脐静脉内皮细胞(HUVECs)中释放阿霉素。润湿性确定的自由堵塞控释系统简单有效，还可以被细胞内生物刺激触发，为未来药物输送和癌症治疗的实际应用提供了新的途径。
To achieve an excellent delivery effect of drug, stimuli-responsive nano "gate" with physical blockage units is usually constructed on the surface of the mesoporous silica nanocarriers (MSNs). In nature, the aquaporins in cell membrane can control the transport of water molecules by regulating the channel wettability, which is resulted from the conformational change of amino acids in the channel. Inspired by this phonomenon, herein a new concept of free-blockage controlled release system is proposed, which is achieved by controlling the wettability of the internal surface of nanopores on MSNs. Such a new system is different from the physical-blockage controlled release system, which bypasses the use of nano "gate" and overcomes the limitations of traditional physical blockage system. Moreover, further studies have shown that the system can selectively release the entrapped doxorubicin in human breast adenocarcinoma (MCF-7) cells triggered by intracellular reactive oxygen species (ROS) but not in normalhuman umbilical vein endothelial cells (HUVECs) containing ROS with low levels. The wettability-determined free-blockage controlled release system is simple and effective, and it can also be triggered by intracellular biological stimuli, which provides a new approach for the future practical application of drug delivery and cancer therapy.