DNA repair in the archaea-an emerging picture.
DNA repair in the archaea-an emerging picture.
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DOI：
10.1093/femsre/fuy020
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发表时间：
2018-07
影响因子：
11.3
通讯作者：
M. F. White;T. Allers
中科院分区：
文献类型：
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作者：
M. F. White;T. Allers
长期以来，人们对古生菌的DNA修复途径一直很感兴趣，主要有两个原因。首先，许多古生菌生活在极端环境中，在那里DNA的物理损伤速度会加快。可以合理地预计，这些古生菌具有特别健壮或新颖的DNA修复途径来应对这一点。其次，古生菌长期以来被认为是与细菌截然不同的一个谱系，并与真核生物有着密切的关系，特别是在它们的信息处理系统中。最近的发现表明，真核生物起源于古生界，特别是与大头门和洛基古菌相关的谱系。因此，古生菌DNA修复蛋白和途径可以代表一个有用的模型系统。本文综述了古生物DNA修复过程的最新研究进展，包括碱基切除修复、核苷酸切除修复、错配修复和双链断裂修复。这些进展是在生命三个领域的进化和关系的新图景的背景下讨论的。
There has long been a fascination in the DNA repair pathways of archaea, for two main reasons. Firstly, many archaea inhabit extreme environments where the rate of physical damage to DNA is accelerated. These archaea might reasonably be expected to have particularly robust or novel DNA repair pathways to cope with this. Secondly, the archaea have long been understood to be a lineage distinct from the bacteria, and to share a close relationship with the eukarya, particularly in their information processing systems. Recent discoveries suggest the eukarya arose from within the archaeal domain, and in particular from lineages related to the TACK superphylum and Lokiarchaea. Thus, archaeal DNA repair proteins and pathways can represent a useful model system. This review focuses on recent advances in our understanding of archaeal DNA repair processes including base excision repair, nucleotide excision repair, mismatch repair and double-strand break repair. These advances are discussed in the context of the emerging picture of the evolution and relationship of the three domains of life.